FN: Nephritic Syndrome/Acute GN Flashcards Preview

Final Notes > FN: Nephritic Syndrome/Acute GN > Flashcards

Flashcards in FN: Nephritic Syndrome/Acute GN Deck (12):
1

Description

Haematuria (macro/micro) + red cell casts
Proteinuria - oedema (esp. periorbital)
Hypertension
Oliguria and progressive renal impairment

2

Causes

1. Proliferative/post-streptococcal
2. Cresentic/RPGN

3

Proliferative/Post-strep features

1. young child develops malaise and nephritic syndrome with smoky urine 1-2 wks after sore throat or skin infection
2. Raised ASOT
3. reduced CS

4

Proliferative/Post-strep biopsy

IgG and Cs deposition

5

Proliferative/Post-strep Rx

supportive

6

Proliferative/Post-strep prognosis

95% of children fully revocer
Minority develop RPGN

7

Cresentic/RPGN description

Most aggressive GN whcih can - ESRF in days

8

Cresentic/RPGN classification

Type 1: Anti-GBM (Good pastures)
Type 2: Immune complex deopsition
Type 3: Pauci Immune

9

Cresentic/RPGN type 1

Ab to NC domain on collagen 4
HAematuria and haemoptysis
CXR show infiltrates

10

Cresentic/RPGN type 1 Rx

Plasmapheresis and immunosuppression

11

Cresentic/RPGN Type 2

Complication of any immune complex deposition -->
1. Bergers
2. Post0strep
3. Endocarditis
4. SLE

12

Cresentic/RPGN Type 3

cANCA: Wegners
pANCA: microscopic polyangitis, Churg strauss
Even if ANCA +ve may still be idiopathy i.e. no features of systemic vasculitis

Decks in Final Notes Class (196):