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Flashcards in FN: SLE Deck (20):
1

Definition

Multisystemic autoimmune inflammatory disease in which autoAbs to a variety of autoantigens result in the formation and deposition of immune complexes

2

Epi

Prev: 0.2%
Sex: F>>M = 9:1
Age: Child-bearing age
Genetic: increased in Afro-Caribs and ASians

3

Features

Relapsing, remitting history
Constitutional symptoms: fatigue, wt loss, fever, myalgia

4

Way to remember features

A RASH POINst an MD

5

Features of SLE

Arthritis
ANA
Serositis
Haematological
Photosensitivity
Oral ulcers
Immune phenomenon
Neurological
Malar Rash
Discoid Rash

6

Arthritis in SLE

Non erosive, involving peripheral joints
Jaccouds: reducible deforming arthopathy

7

Renal

Proteinuria and increased BP

8

ANA

positive in 95%

9

Serositis

Pleuritis: pleuritic pain, dyspnoea, effusion
Pericarditis: chest pain relieved by sitting forwards

10

Haematological

AIHA
reduced WCC
Reduced platelets

11

Immune phenonmenon

Anti-dsDNA
Anti-Sm
Anti-phospholipid

12

Neurological

Seizures, pyschosis

13

Malar rash

Facial erythema spring the nasolabial folds

14

Discoid Rash

Erythema - pigmented hyperkeratotic papules - atrophic depressed lesions
Mainly affects face and chest

15

Monitoring disease activity

Anti-dsDNA titres
Complement: reduced C3 and Cd
increased ESR

16

OTher investigations

Bloods: FBC, U and E, CRP clotting (usually normal)
Urine:stix, PCR

17

Drug induced Lupus
Cause

Procainamide,
phenytoin,
hydralazine,
isoniazid

18

Ab results

Anti-histone Abs in 100%

19

Signs

Mostly skin and lungs

20

Cure

Disease remits if drug stopped

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