FN: GI Polyps Flashcards Preview

Final Notes > FN: GI Polyps > Flashcards

Flashcards in FN: GI Polyps Deck (17):
1

Inflammatory Pseudopolyps

Regenerating islands of mucosa in UC

2

Hyperplastic Polyps

1. Piling up of goblet cells and absorptive cells
2. Serrated surface architecture
3. No malignant potential

3

Hamartomatous

1. Tumour-like growths composed of tissues present at site where they develop
2. Sporadic or part of familial syndromes
3. Juvenile polyp: solitary hamartoma in children "cheery on a stalk"

4

Neoplastic

1. Tubular or villous adenomas
2. usually asympto
3. May have blood/mucus PR, tenesmus

5

Other Hamartomatous Polyposis Sundromes

Juvenile Polyposis
Cowden syndrome

6

Juvenile

Autosomal dominant
>10 hamartomatous polyps
raised CRC risk: need surveilland and polypectomy

7

Cowden syndrome

auto dominant
Macrocephaly + skin stigmata
Intestinal hamrtomas
Raised risk of extra-intestinal Ca

8

FAP

Autosomal dominant
APC gene on 5q21

9

FAP presentation

100-1000s of adenomas by 16yrs
- mainly in large bowel
- Also stomach and duodenum (near ampulla)

10

FAP prognosis

100% develop CRC, often by 40yrs

11

FAP association

With congenital hypertrophy of the retinal pigment epithelium (CHPRE)

12

FAP Mx

1. Prophylactic colectomy before 20 yrs
2. total colectomy + IRA : requires life-long stump surveillance
3. Proctocolectmy + IPAA
4. Remain @ risk of Ca in stomach and duodenum: regular endoscopic screening

13

HNPCC

Autosomal dominan
Mutation of mismatch repair enzyymes e.g. MSH2 on Chr 2p
Commonest cause of hereditary CRC: 3% of all CRC

14

HNPCC presentation

Lynch 1: right sided CRC
Lynch 2: CRC + gastric, endometrial, prostate, breast

15

Diagnosis 3,2,1 rule

>3 family members over 2 generations with one

16

Peutz-jeghers syndome

autosomal dominant
STK11 muttions

17

Peutz-jeghers presentation

1. 10-15 yrs
2. Mucocutaneous hyperpigmentation: macules on palms, buccal mucosa
3. Multiple GI hamartomatous polyps
-Intussusception
- Haemorrhage

4. Raised Ca risk
-CRC, pancreas, breast, lung, ovaries, uterus

Decks in Final Notes Class (196):