FN: Viral Hepatitis Flashcards Preview

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Flashcards in FN: Viral Hepatitis Deck (12):
1

Hep A
Spread
Cause

FO
Seafood, especially abroad

2

Hep B
Spread
Cause

IV
Blood, body fluids, babies (vertical)

3

Hep C
Spread
Cause

IV
Mainly blood, less vertical cf, HCV

4

Hep D
Spread
Cause

IV
Dependant on prior HBV infection

5

Hep E
Spread
Cause

Developing world

6

Presentation Prodromal Phase

􏰀 Seen particularly in HAV and BV
􏰀 Flu-like, malaise, arthralgia, nausea
􏰀 Distaste for cigarettes in Hep A

7

Icteric Phase

􏰀1. Acute jaundice in A>B>C (99, 75 and 25%)
􏰀 2. Hepatitis
􏰁 - Abdo pain
- 􏰁 Hepatomegaly
-􏰁 Cholestasis: dark urine, pale stools

􏰀2. Extrahepatic features due to complexes (esp. Hep B) 􏰁
- Urticaria or vasculitic rash
􏰁 - Cryoglobulinaemia
􏰁 - PAN
􏰁- GN
- 􏰁 Arthritis

8

Chronic Phase

􏰀 Mainly HCV and childhood HBV
􏰀 Cirrhosis → ↑ risk of HCC

9

Hep B

􏰀 Carrier: 10%
􏰁 HBsAg +ve > 6mo
􏰀 Chronic hepatitis: 10%
􏰀 Cirrhosis: 5%

10

Hep C

􏰀 Carrier: 80%
􏰁 HCV RNA+ve >6mo
􏰀 Chronic hepatitis: 80%
􏰀 Cirrhosis: 20%

11

Ix

- FBC, LFTs, clotting
􏰀- Hep A/B/C serology

12

Rx

􏰀 Supportive
􏰁 - No EtOH
- 􏰁 Avoid hepatotoxic drugs (e.g. aspirin)
􏰀 Anti-viral
- 􏰁 Indicated in chronic disease
􏰁- HBV: PEGinterferon
􏰁 - HCV: PEGinterferon + ribavarin
- 􏰁 Seroconversion: HBV – 40%, HCV – 10%

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