FN: Thyroid drugs Flashcards Preview

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Flashcards in FN: Thyroid drugs Deck (11):
1

Thyroid drugs

Thyroxine
Carbimazole
Propythiouracil
Radioiodine

2

Thyroxine SE

Precipitation of heart failure
Osteopenia
AF
Over-Rx - hyperthyroidism

3

Thyroxine Interactions

W+

4

Thyroxine note

Introduce slowly in elderly

5

Carbimazole
Propythiouracil MOA

Thionamides
-Thyroperoxidase inhibitos
- Prevent iodination of tyrosine --> reduced T4/T3 synthesis

Carbimazole is a pro-drug - converted to methimazole

6

Carbimazole
Propythiouracil SE

Agranulocytes
-often transient and benign

Hypersensitivity: rash, pruritis

Hepatitis

7

Carbimazole
Propythiouracil Contrainidications

Pregnancy
Children
Tracheal compression - do surgery

8

Carbimazole
Propythiouracil other

Propythiouracil is reserved for those intolent of carbimazole due to risk of hepatitis

Titrate to normal TSH or block and replace

9

Radioiodine: MOA

Radioiodine is localised to thyroid - destructino of gland

10

Radioiodine SE

Hypothyroidism
Can precipitate thyroid storm

11

Radioiodine Other

Stop thionamide before use

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