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Flashcards in fong VIII Deck (22):
1

how much Ca2+ is filtered at the glomerulus?

~60%

2

do the kidneys secrete Ca2+?

no

3

how is calcium absorbed in the proximal tubules?

passive, paracellular

4

how is calcium absorbed in the distal tubules?

transcellular

5

what regulates calcium at the level of the bone and kidney?

PTH

6

1, 25 dihroxvitamin D stimulates what?

intestinal Ca2+ uptake

7

Thiazide diuretics to what to DT Ca2+ absorption?

enhance it

8

resting membrane potential, Vm, is determined largely by what?

membrane K+ conductance

9

what happens when K+ is in excess?

K+ is excreted

10

what 2 things happen in acute regulation of K+ in ECF?

-uptake into ICF (Na+/K+ ATPase)
-skeletal muscle is a major reservoir

11

what 2 things happen in long term regulation of ECF K+?

-fecal loss
-renal excretion

12

most of the K+ in the body resides where?

in the intracellular space

13

what cells secrete K+ in the CD?

principle cells

14

K+ is inhibited by what?

acidosis

15

K+ is stimulated by what?

alkalosis

16

T/F: aldosterone stimulates ROMK.

true

17

at a low K+ load:

ROMK is sequestered
BK is closed

18

at a modest K+ load:

ROMK is open
BK is closed

19

at a high K+ load:

ROMK is open
BK is open

20

how are BK channels regulated?

by flow

21

acidic ECF = hyper or hypo kalemia

hyperkalemia
-acidic inhibits ROMK

22

alkaline ECF = hyper or hypo kalemia

hypokalemia
-alkaline actives ROMK