GI Pharm

Question 1

name 3 histamine H2 receptor agtangonist

Answer 1

cimetidine (tagemet)
Rantididine (zantac)
Famotidine (pepcid)

Question 2

histamine H2 receptor agtangonist

how do they work

Answer 2

antagonism of Gastric H2 receptors inhibits hydrochloric acid production and raises pH

Question 3

histamine H2 receptor agtangonist

what is special about cimetidine?

Answer 3

inhibits CYP450 enzymes- thus interfering with metabolism of other drugs metabolized by liver
theophylline
coumadin
phenytoin

Question 4

name a gastric motility agent

Answer 4

metoclopramide (reglan)

Question 5

gastric motility agent

what is the action of reglan

Answer 5

increases tone of LES
Increases gastric motility
decreases tone of pyloric sphincter
relaxation of duodenum

Question 6

the incidence ad severity of aspiration pneumonitis are reduced if what 2 things occur

Answer 6

pH above 2.5

gastric volume less than 25mL (0.4mL.kg)

Question 7

Antiemetics:

name some competitive dopamine antagonist

Answer 7

droperidol (inapsine)
Prochlorperazine (compazine)
Metoclopramide (reglan)

Question 8

Antiemetics: Dopamine antagonist

b/c these drugs have dopamine receptor antagonist activity they should be avoided in what pts

Answer 8

Parkinson’s dz

Question 9

Antiemetics: Antimuscarinic

name one

Answer 9

scopolamine

Question 10

Antiemetics: Selective serotonin-3 (5-hydtoxytryptamine-3,5-HT3) antagonist.
Name the one drug

Answer 10

Ondansetron (zofran)

Question 11

Antiemetics:

how does ondansetron work

Answer 11

blocks both central and peripheral 5-HT3 receptors.

Question 12

Antiemetics:

5-HT is another name for what

Answer 12

serotonin