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► Med Misc 44 > GI Pharm > Flashcards

Flashcards in GI Pharm Deck (12)
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1
Q

name 3 histamine H2 receptor agtangonist

A

cimetidine (tagemet)
Rantididine (zantac)
Famotidine (pepcid)

2
Q

histamine H2 receptor agtangonist

how do they work

A

antagonism of Gastric H2 receptors inhibits hydrochloric acid production and raises pH

3
Q

histamine H2 receptor agtangonist

what is special about cimetidine?

A

inhibits CYP450 enzymes- thus interfering with metabolism of other drugs metabolized by liver
theophylline
coumadin
phenytoin

4
Q

name a gastric motility agent

A

metoclopramide (reglan)

5
Q

gastric motility agent

what is the action of reglan

A

increases tone of LES
Increases gastric motility
decreases tone of pyloric sphincter
relaxation of duodenum

6
Q

the incidence ad severity of aspiration pneumonitis are reduced if what 2 things occur

A

pH above 2.5

gastric volume less than 25mL (0.4mL.kg)

7
Q

Antiemetics:

name some competitive dopamine antagonist

A

droperidol (inapsine)
Prochlorperazine (compazine)
Metoclopramide (reglan)

8
Q

Antiemetics: Dopamine antagonist

b/c these drugs have dopamine receptor antagonist activity they should be avoided in what pts

A

Parkinson’s dz

9
Q

Antiemetics: Antimuscarinic

name one

A

scopolamine

10
Q

Antiemetics: Selective serotonin-3 (5-hydtoxytryptamine-3,5-HT3) antagonist.
Name the one drug

A

Ondansetron (zofran)

11
Q

Antiemetics:

how does ondansetron work

A

blocks both central and peripheral 5-HT3 receptors.

12
Q

Antiemetics:

5-HT is another name for what

A

serotonin

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