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Flashcards in GI Pharm Deck (12)
1

name 3 histamine H2 receptor agtangonist

cimetidine (tagemet)
Rantididine (zantac)
Famotidine (pepcid)

2

histamine H2 receptor agtangonist
how do they work

antagonism of Gastric H2 receptors inhibits hydrochloric acid production and raises pH

3

histamine H2 receptor agtangonist
what is special about cimetidine?

inhibits CYP450 enzymes- thus interfering with metabolism of other drugs metabolized by liver
theophylline
coumadin
phenytoin

4

name a gastric motility agent

metoclopramide (reglan)

5

gastric motility agent
what is the action of reglan

increases tone of LES
Increases gastric motility
decreases tone of pyloric sphincter
relaxation of duodenum

6

the incidence ad severity of aspiration pneumonitis are reduced if what 2 things occur

pH above 2.5
gastric volume less than 25mL (0.4mL.kg)

7

Antiemetics:
name some competitive dopamine antagonist

droperidol (inapsine)
Prochlorperazine (compazine)
Metoclopramide (reglan)

8

Antiemetics: Dopamine antagonist
b/c these drugs have dopamine receptor antagonist activity they should be avoided in what pts

Parkinson's dz

9

Antiemetics: Antimuscarinic
name one

scopolamine

10

Antiemetics: Selective serotonin-3 (5-hydtoxytryptamine-3,5-HT3) antagonist.
Name the one drug

Ondansetron (zofran)

11

Antiemetics:
how does ondansetron work

blocks both central and peripheral 5-HT3 receptors.

12

Antiemetics:
5-HT is another name for what

serotonin

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