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Flashcards in Glomerular Disease Details Deck (65)
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61

Pathogenesis of Diabetic Glomerulonephropathy?

- Nonenzymatic glycosylation of GBM --> increased permeability, thickening
- Nonenzymatic glycosylation of efferent arterioles --> increase in GFR --> mesangial expansion --> hyaline arteriosclerosis
- Microalbuminuria

62

What is the most common cause of end-stage renal disease in the U.S.?

Diabetic Glomerulonephropathy

63

Diabetic Glomerulonephropathy LM?

Mesangial expansion
GBM thickening
Eosinophilic nodular glomerulosclerosis (Kimmelstiel-Wilson lesions)

64

Diabetic Glomerulonephropathy treatment?

Ace inhibitor - blocks Ang II --> decrease P at efferent arteriole --> decrease rate of injury

65

Buzzwords for Diabetic Glomerulonephropathy

HYALINE ARTERIOSCLEROSIS
KIMMELSTIEL-WILSON LESIONS