Flashcards in Glomerular Disease Details Deck (65)
Pathogenesis of Diabetic Glomerulonephropathy?
- Nonenzymatic glycosylation of GBM --> increased permeability, thickening
- Nonenzymatic glycosylation of efferent arterioles --> increase in GFR --> mesangial expansion --> hyaline arteriosclerosis
What is the most common cause of end-stage renal disease in the U.S.?
Diabetic Glomerulonephropathy LM?
Eosinophilic nodular glomerulosclerosis (Kimmelstiel-Wilson lesions)
Diabetic Glomerulonephropathy treatment?
Ace inhibitor - blocks Ang II --> decrease P at efferent arteriole --> decrease rate of injury