Flashcards in gold usmle: cardio pharm Deck (58)
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31
TPA
Binds to fibrin clots & activates plasminogen on the spot. Short t1/2, given IV.
32. Does not discriminate b/t fibrin-based clots= bleeding & stroke complications arise
32
Streptokinase
From bacteria= allergies arise. Can see excess bleeding in post-op pts.
33
Urokinase
Human source. ↑ plasmin. Can see excess bleeding in post-op pts.
34
Colestipol
Bile acid sequestrants. Interrupt bile acid reabsorption= ↑↑ LDL uptake. Cholestyramine same MOA.
35
Lovastatin
HMGCoA reductase(-)= ↑ LDL-r synthesis. Pravastatin/ Mevastatin same MOA.
36
Losartan
↓ Aldosterone. ↑ Renin 2-3xs
37
Diazoxide
Txt insulinomas. Not balanced vasodilator= onlt dilates arterial smooth muscle
38
Clonidine
Central α2(+). ↓ TPR via ↓ symapthetic effect
39
Methyldopa
Central α2(+). (++) Coombs= Hemolytic anemia
40
Phenytoin
ClassIb. Reverses mild AV block due to digitoxin toxicity
41
Procainamide
ClassIa. SLE like syndrome.
42
Indopamide
Only Thiazide that will have no effect on cholesterol levels
43
Thiazides
Older black men w/ HTN due to ↑ Renin.
44
β(-)
Young white men w/o asthma (cause bronchospasm)
45
ACEIs
(-) change AI ! AII. (-) Bradykinin inactivation. Captopril/ Enalapril
47. Cause renal failure = use w/ caution in the elderly
46
Epinephrine
↑ contraction rate & force via β1.
49. ↑ systolic but ↓ diastolic BP.
50. ↓ peripheral resistance via β2 vasodilaiton
47
Norepi.
↑ heart rate and ↑ systolic and diastolic BP
52. ↑ peripheral blood vessel resistance
48
Methyldopa
DOC for pregnancy induced HTN
49
Quinidine pre-txt
Atrial arrhythmia pretxt w/ a drug that will ↓ ventricular response: Dig.;β(-); Ca Ch.(-)
50
ClassII
β(-) ↓risk fo reinfarction & sudden death following MI
51
Gray man
Amiodarone: ClassIII antiarrhythmia
52
Beperidil
Ca Ch(-). Limited clinical use due to Torsades de Pointes
53
ACEIs
Vasodilate renal efferents > than afferent arterioles: ↓GFR & Filtration pressure
59. ↓ Diabetic renal failure progression
54
Adenosine
Its receptor is blocked by Methylxanthines (ie
Theophyline)
61. Favored for the Txt of Reentrant Supra Ventricular Tachycardia
55
Enoxaparin
Low molecular weight heparin = Oral anticoagulant
56
Isoproterenol
↑HR & ↓MAP
57
Variant angina
Use Ca Ch. (-)r ie Nifedipine
58
