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Flashcards in gold usmle: cardio pharm Deck (58)
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31

TPA

Binds to fibrin clots & activates plasminogen on the spot. Short t1/2, given IV.
32. Does not discriminate b/t fibrin-based clots= bleeding & stroke complications arise

32

Streptokinase

From bacteria= allergies arise. Can see excess bleeding in post-op pts.

33

Urokinase

Human source. ↑ plasmin. Can see excess bleeding in post-op pts.

34

Colestipol

Bile acid sequestrants. Interrupt bile acid reabsorption= ↑↑ LDL uptake. Cholestyramine same MOA.

35

Lovastatin

HMGCoA reductase(-)= ↑ LDL-r synthesis. Pravastatin/ Mevastatin same MOA.

36

Losartan

↓ Aldosterone. ↑ Renin 2-3x’s

37

Diazoxide

Txt insulinomas. Not balanced vasodilator= onlt dilates arterial smooth muscle

38

Clonidine

Central α2(+). ↓ TPR via ↓ symapthetic effect

39

Methyldopa

Central α2(+). (++) Coombs= Hemolytic anemia

40

Phenytoin

ClassIb. Reverses mild AV block due to digitoxin toxicity

41

Procainamide

ClassIa. SLE like syndrome.

42

Indopamide

Only Thiazide that will have no effect on cholesterol levels

43

Thiazides

Older black men w/ HTN due to ↑ Renin.

44

β(-)

Young white men w/o asthma (cause bronchospasm)

45

ACEIs

(-) change AI ! AII. (-) Bradykinin inactivation. Captopril/ Enalapril
47. Cause renal failure = use w/ caution in the elderly

46

Epinephrine

↑ contraction rate & force via β1.
49. ↑ systolic but ↓ diastolic BP.
50. ↓ peripheral resistance via β2 vasodilaiton

47

Norepi.

↑ heart rate and ↑ systolic and diastolic BP
52. ↑ peripheral blood vessel resistance

48

Methyldopa

DOC for pregnancy induced HTN

49

Quinidine pre-txt

Atrial arrhythmia pretxt w/ a drug that will ↓ ventricular response: Dig.;β(-); Ca Ch.(-)

50

ClassII

β(-) ↓risk fo reinfarction & sudden death following MI

51

“Gray man”

Amiodarone: ClassIII antiarrhythmia

52

Beperidil

Ca Ch(-). Limited clinical use due to Torsades de Pointes

53

ACEIs

Vasodilate renal efferents > than afferent arterioles: ↓GFR & Filtration pressure
59. ↓ Diabetic renal failure progression

54

Adenosine

Its receptor is blocked by Methylxanthines (ie… Theophyline)
61. Favored for the Txt of Reentrant Supra Ventricular Tachycardia

55

Enoxaparin

Low molecular weight heparin = Oral anticoagulant

56

Isoproterenol

↑HR & ↓MAP

57

Variant angina

Use Ca Ch. (-)r ie… Nifedipine

58

Contraindicated in
CHF

β (-)r = you don’t want to ↓ the heart’s pumping strength