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Flashcards in Handout 16 Deck (21):
1

why is the plaque formation essential for gingivitis and periodontitis?

pellicle formation
oral bacteria is initially attach to the pellicle AND NOT DIRECTLY TO ENAMEL
biofilms= quorum sensing

2

this hypothesis states that key organisms cause the disease. treat these with antibitoics

specific plaque hypothesis

3

diesae is caused by a combo of non specific organisms- plaque causes the disease. treat by "reducing plaque" to some specific number

non specific

4

host mounts inflammatory response to plaque, increased GCF flow (feeds Gram negative anaerobes), flora shift, increased virulence factors and damage
B. Treatment - reduce plaque to an “acceptable level” and maintain of healthy ecosystem

ecological plaque hypothesis
adds the host to this that will obviously mount an inflammatory response to the plaque. increased GCF flow = feeds the gram negative anaerobes, flora shift, increased virulence factors and damage.
treat by reducing plaque to an acceptable level
maintain healthy ecosystem

5

- cause or contribute to homeostasis breakdown – other organisms called pathobionts then are able to cause damage. P. gingivalis is likely a keystone for perio disease.

keystone organisms.
the homeostasis breakdown.

6

commensals that can go bad – these organisms cause the damage when conditions are right. For perio disease these include T. denticola, Tannerella forsythia and Aggregatibacter actinomycetemcomitans

pathobionts
these include T. denticola, tunneler, forsythia, agregatiabacter, actionomycetemoiamts.

7

what is the host response in periodontitis?

C. Host Response- note that pathobionts must survive and thrive despite inflammation. Th17 response is destructive in periodontal disease.

8

first organisms thought to be the case of disease in caries?

Koch... he just suspected that a microorganism causes this

9

caries are a _____ infection

endogenous
they're thought to be part of the host flora

10

evidence for caries causing bacteria?

evidence of mutants streptococci in various carious lesions
isolates show sucrose consuming

11

inorganic ions from saliva

reminerilization

12

whats the most cariogenic sugar?

sucrose! glucose and fructose are less.
frequency and type is the most improtant

13

what does stephen curve show?

shows the time it takes to restore pH after snacking for instance.
during this time, pH goes to normal and enamel stops dissolving
saliva can remineralize dissolved enamel

14

what bacteria are the most acidiogenic and acidic?

strep mutans

15

can stephen curve asses the cariogenicity of foods?

yes! tooth friendly foods labeled in europe.
tells you how much time needed to come to the normal pH

16

ability to synthesize both extracellular and intracellular (food) polysacchradie from what?

sucrose

17

can the attachment of srep mutants happen without sucrose?

it is thought so

18

what kind of molecules on the mutans strep cell surface are important for binding to tooth structure?

LECTIN like molecules.

19

what do the lectin like molecules bind to on the tooth surface?

glycoprotein pellicle (saliva)
coating the tooth surface. some timbre can bind to glyocoproteins on the tooth surface.

20

do most bacteria have surface receptors?

not most.
mutants does and some like antiomyeces and songs make dextran. most plaque bacteria do not make surface receptors for gluons and unlike mutants, streptococci o not accumulate in plaque through dextran gluten ginding

21

do you usually see lactobacilli before the development of caries?

no, rarely isolated before the development of caries.