Flashcards in Handout 16 Deck (21):
why is the plaque formation essential for gingivitis and periodontitis?
oral bacteria is initially attach to the pellicle AND NOT DIRECTLY TO ENAMEL
biofilms= quorum sensing
this hypothesis states that key organisms cause the disease. treat these with antibitoics
specific plaque hypothesis
diesae is caused by a combo of non specific organisms- plaque causes the disease. treat by "reducing plaque" to some specific number
host mounts inflammatory response to plaque, increased GCF flow (feeds Gram negative anaerobes), flora shift, increased virulence factors and damage
B. Treatment - reduce plaque to an “acceptable level” and maintain of healthy ecosystem
ecological plaque hypothesis
adds the host to this that will obviously mount an inflammatory response to the plaque. increased GCF flow = feeds the gram negative anaerobes, flora shift, increased virulence factors and damage.
treat by reducing plaque to an acceptable level
maintain healthy ecosystem
- cause or contribute to homeostasis breakdown – other organisms called pathobionts then are able to cause damage. P. gingivalis is likely a keystone for perio disease.
the homeostasis breakdown.
commensals that can go bad – these organisms cause the damage when conditions are right. For perio disease these include T. denticola, Tannerella forsythia and Aggregatibacter actinomycetemcomitans
these include T. denticola, tunneler, forsythia, agregatiabacter, actionomycetemoiamts.
what is the host response in periodontitis?
C. Host Response- note that pathobionts must survive and thrive despite inflammation. Th17 response is destructive in periodontal disease.
first organisms thought to be the case of disease in caries?
Koch... he just suspected that a microorganism causes this
caries are a _____ infection
they're thought to be part of the host flora
evidence for caries causing bacteria?
evidence of mutants streptococci in various carious lesions
isolates show sucrose consuming
inorganic ions from saliva
whats the most cariogenic sugar?
sucrose! glucose and fructose are less.
frequency and type is the most improtant
what does stephen curve show?
shows the time it takes to restore pH after snacking for instance.
during this time, pH goes to normal and enamel stops dissolving
saliva can remineralize dissolved enamel
what bacteria are the most acidiogenic and acidic?
can stephen curve asses the cariogenicity of foods?
yes! tooth friendly foods labeled in europe.
tells you how much time needed to come to the normal pH
ability to synthesize both extracellular and intracellular (food) polysacchradie from what?
can the attachment of srep mutants happen without sucrose?
it is thought so
what kind of molecules on the mutans strep cell surface are important for binding to tooth structure?
LECTIN like molecules.
what do the lectin like molecules bind to on the tooth surface?
glycoprotein pellicle (saliva)
coating the tooth surface. some timbre can bind to glyocoproteins on the tooth surface.
do most bacteria have surface receptors?
mutants does and some like antiomyeces and songs make dextran. most plaque bacteria do not make surface receptors for gluons and unlike mutants, streptococci o not accumulate in plaque through dextran gluten ginding