Immunity

Question 1

Sjorgens Syndrome and Tx

Answer 1

A chronic autoimmune disorder where moisture producing glands are attacked by WBC causing dry mouth, eyes, throat, skin, and vagine
Tx: treat symptoms: sugar less gum, lube, regular dental appointments, lukewarm water and mild soap. Avoid decongestants and irritants (caffeine, alcohol, nicotine)

Question 2

What is Systemic Lupus Erythemathosus (SLE)

Answer 2

When the body’s immune system produces antibodies that attack the bodyis tissues and cells. It has flares and remissions

Question 3

What is scleroderma and its complications

Answer 3

Scleroderma is the overproduction of collagen causing thigtening and hardening of skin/connective tissue
Complications: renal crisis, malignant hypertension, raynaud’s, pulmonary fibrosis, heartburn, and dysphasia

Question 4

S/S of SLE

Answer 4

• Butterfly rash on face (usually related to sun exposure)
• oral ulcers
• Can affect skin, muscles, joints, kidneys, heart, lung, blood vessels and CNS, chest pain on inspiration, photosensitivity, pancytopenia (

Question 5

Complications of SLE

Answer 5

1. Lupus nephritis: inflammation of kidneys d/t vascular inflammation
2. Pleural Effusions: inflammation of pleural tissue causing a build up of fluid
3. Vasculitis and increased presence of procoagulant antibodies: increased risk of DVT

Question 6

Tx for SLE

Answer 6

• NSAIDs
• Prednisone
• Hydroxychloroquine (reduces immune activity)

Question 7

What is Rheumatoid Arthritis

Answer 7

Chronic autoimmune disease that causes inflammation and damage to they synovial joint.
Tx: methotrexate, NSAIDS, Glucocorticoids (prednisone)

Question 8

How is OA different from RA

Answer 8

OA is not autoimmune and has a shorted period of morning joint stiffness

Question 9

What is Malignant Hypertermia

Answer 9

A rare, inherited life threatening reaction typically to anaesthesia but can also be triggered by stress, heat, trauma.
Causes muscle breakdown, rhabdo, and extreme fever
Tx: dantrolene

Question 10

What is Steven-Johnson Syndrome/Toxic epidermal necrosis

Answer 10

Immune mediated skin reaction caused by abx, allopurinol, anticonvulsant, NSAIDs, sulfasalazine.
S/S: start with flu like symptoms 4-28 days after exposure then developes into rash with blisters. If rash >30% of body it is considered toxic epidermal necrosis