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Flashcards in immunology Deck (38)
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31

Classical pathway

Complement pathway involving IgM or IgG, effect of humoral immunity. C1,2,4. IgG/M binds and activate C1 (q,r,s) to convert C2,4 to a,b which bind to make C3 convertase

32

Alternative pathway

Innate immunity complement pathway. Factor B,D, properdin. Factor B+trace c3b makes c3bB which factor D splits to c3bBb (c3 convertase) +Ba. Very unstable unless bound to bacterial surface

33

Lectin pathway

Innate immunity complement pathway. MBL (mannose binding lectin) protein replaces C1. MBL,c2,4

34

Release of anaphylatoxins

C5a, C3a. Increase vascular permeability

35

Release of chemtactic factors

C5a. Attract neutrophils

36

MAC

membrane attack complex. C5b +6,7,8,9

37

C1 inhibitor

dissociates activated c1

38

Hereditary angioneurotic edema

HANE. C1 inhibitor deficicency. Sym: GI cramps, vomiting, edema