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Flashcards in Imp Fungal Infections of the Mouth Deck (43):
1

what are fungi

eukaryotes

2

what is ubiquitous

saprophylytic or parasiitc

3

what is saprophytic

break down dead/organic matter

4

what are some characteristics of fungi

repro sexual/asexual
unicellular or filamentous vegetative strutures
budding, binary fission
surrounded by chitin cell wall

5

what are the four genera fungi

candida
cryptococcus
apergillus
pneumocystis

6

what are some common fungal related infection

athletes foot
ringworm
vulvovaginal candidiasis
aspergillosis

7

what are the two types of fungi

yeast mould
dimorphic and polymorphic

8

what are some yeats

single oval cells often reproduce by budding

9

what are moulds

multicellular and comp of tubules or filaments called hyphae

10

what is a mycelium

mass of hyphae

11

what is ascomycetes

candida sp

12

what is the marriage are of candida sp

35%
commonset cause infections

13

what are some common sp of candida found in the mouth

albicans (.90%)
glabrata (15-20%)
diff resistant natural systems

14

what si the structure of c albicans

oval budding
blastophores
pseudohyphae

15

what are chlamydospores

formed from c albicans
forms round thick walls resting structures

16

where does c albicans colonise

mouth
GI treat
skin
female genital tact

17

what superficial candidosis

pseudomembranous candidosis PMC

18

what is the superficial candidiasis mucosal infection

thrush
white pseudomem on buccal mucosa/vagina
easily removed by wipe
common in woman

19

what are some other ski infections assc with superficial candidosis

intertrigo
nappy rash
paronychia
HIV infection

20

what does superificl candidosis effect

mainly skin nd epi surfaces

21

what is the other type of candidosis

mucocutaneous
involve bthskina nd underlying mucosa

22

what is CMC

chronic mucocutaneous Candidosis

23

what is CMC described as

disease of the diseased

24

what is the condition of CMC

rare
persistent infection o mouth
skin and mucosa involved
been with t cell def

25

what are the systemic/deep infection of candidossis

occur in major organs following candidaemia (blood infection)
can be fatal if untreated

26

what happens in systemic candidosis

initial reaction
- lower resp tract
- candidaemia
fungi migrate
fatal if untreated

27

what are the risk factors of systemic candidiosi

seriously ill patients
heart sugery
long term immunosuppression or drug therapy

28

what is oral candidiasis presentations

PMC thrush
erythematous candidosis
angular cheitits
chronic hyperplasia candidosis

29

how does erythematous candidosis come about orally

denture wearing most common

30

how treat erythematous candidosis

antibiotics
topical steroids

31

what is seen form erythematous candisoss

red swollen inflamed mucosae
to area of upper denture
c albicans
treat - topical, cleaning

32

what causes antibiotic ore mouth

suppression of normal flora
overgrow c albicans
broad spec Ab

33

how would treat antibiotic sore mouth

topical anti fungal agents
stop admin Ab

34

what is angular cheitits

erythema and fissures in angular oris
seen denture wearers and vitamin deficiencies
superinfection s aureus

35

what is chronic hyper plastic candidosis

individual lesions candidate leukoplakia
white patches cannot be rubbed off
parakeratinised and hyperplasia

36

what are some risk factors of candidial leukoplakia

denture hygiene
medications
immunosuppression
xerostomia
endocrine disfunction
moisture
smoking
blood disease

37

what is the adherence of c albans like

hyphen - form more adhesive - acrylic
hydrophobic surface
sp adhesins
fibrillar annoprotein

38

what are the host defences/damage of c albicans

secreted proteinases (SAPs)
phospholipase
conc at hyphal tip

39

what is the evolution of morphology and virulence in candida

yeast
pseudohyphae
hyphae

40

what are anti fugal agents

antimycotics commonly prescribed by GDP's

41

what are some anti fungal agents

polygenes - nystatin
imidazole - micronazole
triazole - fluconazole
antimetabolite - fluorocytosine

42

what does nystatin do

bind to ergosterol in fungal lipid mem - make mem leaky

43

what do azoles do

inhibitor of ergosterol formation
used systemically
resistance