M12 Spirochaetes & ANUG Flashcards
(36 cards)
what kind of cell wall does spirochetes have
gm -Ve cell wall
doesnt stain well
spirochetes are fastidious what does this mean
difficult to grow in lab on agar or broth
are spirochetes common in mouth
very common
assc with deep perio pockets
increase with periodontitis
what si struct of spirochetes
helical bac
central protoplasmic cyinder
3–5 axial filaments in outer cell envelope
what si the genus of spirochetes
Treponema
borrelia
what is borrelia burghdorferi
20 sub sp 5 cause disease
what is the disease borrelia burghdorferi cause
lymes disease
what is lames disease
tick bite - zoonotic
slow grow
microaerophilic spirochete
what is the primary infection of lames disease
red spot at bite site the enlarges withal area in middle
red ring
what are the symptoms of lymes disease
headache drowsiness mild fever joint/muscle pain swollen lymph nodes
when does he symptoms take effect
3-30 days post infection
what happens to 15% people after 1-5 weeks after a tick bite
neuro borrelia
- neurological implication
what are the symptoms of euro borrelia
back pain numb feel at bite meningits presntation chornic lyme arthritis inflam heart
what does treponema palladium cause
csyphilus
what are the symptoms implications of csyphilus
painless chancre rash flu like symptoms occasional rash neuro and CV madness
what are the diffenret progressions of csyphilus and time
primary
- 3 days - 3 months
secondary
- 2 weeks - 24 months
latent
- 1-30 years
tertiary
- 1- greater than 30 years
what can congenital syphilus cause
vertical transmission mother to child
- saddle nose
- hutchisons teeth notched incisors
what is used to treat syphilus
penicillin
- 2 million unitsintramuscular Pen G
- 3 injections for latent syphiuls
where are oral treponemes
loose assc at edge sub gingival plaque
what are some oral treponemes
treponema vincentii
treponema denticola (red complex)
treponema oralis
what is T denticola
larger genome the T palladium
most proteolytic member of red complex
attach at to gingival fibroblast
induce cyttoxicty and cell death
what are the stress responses of t denticola
superoxide dimutase (SOD) activity arginine deaminase
what sit he assc of t deneticola with p gingivalis
commonly found assc with each other in chronic perio lesions
congregate
grown in mixed biofilms
what does the relationship of t denticola and p gingivalis show
increasing evidence of synergistic assc between two periopathogens
