M20 Flashcards
(21 cards)
what is sterilisation
process by which all living cells viable spores and viruses are detpryed or moved
what isdisinfection
killing, inhibition or removal of microorganisms that cause disease
what is sanitisation
reduction of microbial population to levels that a re safe for public health
what are some examples of prion based diseases
scrapie = BSE creutzfeldt Jacob Disease GSS fatal familial insomnia Kuru new variant CJD
what are the types of CJD
sporadic
inherited
transmitted
what is themes common CJD
sporadic
what is the pt for sCJD
elderly
dementia
unknown cause
where is highest levels of prion
CNS
retina
sensory ganglia
not blood
what is vCJD
fatal human neurodegenerative condition
transmissible spongiform encephalopathy
spread to humans via unclean inst
what can be found at position 129 on PRNP codon
methionine and valine
what ar ht genotypes of prion P
homozygous MM
homozygous VV
heterozygous MV
what re the symptoms of vCJD
av age 28 dementia sensory unsteady involve moves immobile mute death
what are the effects of vCJD
brain vacuolation
neural apoptosis
accumulate misfiled protease resistant prion protein
hat causes vCJD
scrapie
BSE
protein only hypothesis lead directly to prion
what is a prion
proteinaceous infectious particle
replicate itself in body
what ar the types of prion
PrpC conv to PrpSC (accumulates as plaque)
new cone PrpSC makes more PrpC
explain few features of PrpC
made normally by body
prod in neurons
stability of myelin sheath and memory
identical to PrpSC
what si the amount of PrpSC proportional o
infectivity
what si the life cycle of a prion
uptake via peters patches circa blood accumulates lymphoid enters nerves orcorss BBB accumulates in bain
how is vCJD peripherally dist
lymphoid tissue (tonsil, lymph node, spleen) neural tissue (trigem gang) blood for transfusion
what are some sites for decontamination
cleaning
autoclaving
files and reamers
