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Flashcards in M20 Deck (21):
1

what is sterilisation

process by which all living cells viable spores and viruses are detpryed or moved

2

what isdisinfection

killing, inhibition or removal of microorganisms that cause disease

3

what is sanitisation

reduction of microbial population to levels that a re safe for public health

4

what are some examples of prion based diseases

scrapie = BSE
creutzfeldt Jacob Disease
GSS
fatal familial insomnia
Kuru
new variant CJD

5

what are the types of CJD

sporadic
inherited
transmitted

6

what is themes common CJD

sporadic

7

what is the pt for sCJD

elderly
dementia
unknown cause

8

where is highest levels of prion

CNS
retina
sensory ganglia
not blood

9

what is vCJD

fatal human neurodegenerative condition

transmissible spongiform encephalopathy

spread to humans via unclean inst

10

what can be found at position 129 on PRNP codon

methionine and valine

11

what ar ht genotypes of prion P

homozygous MM
homozygous VV
heterozygous MV

12

what re the symptoms of vCJD

av age 28
dementia
sensory unsteady
involve moves
immobile
mute death

13

what are the effects of vCJD

brain vacuolation
neural apoptosis
accumulate misfiled protease resistant prion protein

14

hat causes vCJD

scrapie
BSE
protein only hypothesis lead directly to prion

15

what is a prion

proteinaceous infectious particle
replicate itself in body

16

what ar the types of prion

PrpC conv to PrpSC (accumulates as plaque)
new cone PrpSC makes more PrpC

17

explain few features of PrpC

made normally by body
prod in neurons
stability of myelin sheath and memory
identical to PrpSC

18

what si the amount of PrpSC proportional o

infectivity

19

what si the life cycle of a prion

uptake via peters patches
circa blood
accumulates lymphoid
enters nerves orcorss BBB
accumulates in bain

20

how is vCJD peripherally dist

lymphoid tissue (tonsil, lymph node, spleen)
neural tissue (trigem gang)
blood for transfusion

21

what are some sites for decontamination

cleaning
autoclaving
files and reamers