Infection: Infections on Surfaces Flashcards Preview

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Flashcards in Infection: Infections on Surfaces Deck (11):
1

What is a surface?

The interface between a solid and either a liquid or a gas

2

What are commensals?

Microorganisms carried on skin and mucosal surfaces that are normally harmless or even beneficial.
They only cause problems when they transfer to other sites

3

What are the different modes of transmission causing people to get infections?

Invasion - direct
Migration - bacteria travelling from one location to another where it isnt supposed to be
Innoculation - bacteria growing on a prosthetic joint
Haematogenous - spread via the blood

4

Give some examples of natural surface infections

External: UTI, pneumonia, cellulitis
Internal: endocarditis, osteomyelitis

5

Give some examples of prosthetic surface infections

IV lines, dialysis catheters, cardiac valves, prosthetic joints

6

What types of MOs cause prosthetic valve endocarditis?

Less than 1 year post op = staph aureus, candida, viridans strep
More than 1 year post op: coag neg staph

7

What type of MOs cause prosthetic joint infections?

Staph aureus or coag neg staph

8

What type of MOs cause cardiac pacing wire endocarditis?

Staph aureus or coag neg staph

9

What is the process that leads to infection at surfaces?

Adherence to host cells or prosthetic surface (pili or fimbrae help bind to surface)
Biolfilm formation (bacteria produce a biofilm which protects them from destruction from host and antibacterials)
Invasion and multiplication

10

How can infections at surfaces be prevented?

Natural surfaces: maintain integrity, prevent colonisation, remove bacteria
Prosthetic surfaces: prevent contamination, inhibit surface colonisation, remove bacteria

11

How do we manage infected surfaces?

Identify the infecting organism - blood culture or tissue/prosthetic culture
Use antibacterials
Remove the prosthetic
May need surgery to resect the infected material

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