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Flashcards in Infectious Disease 4 Deck (80)
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1

Two main types of vector borne diseases?

Intracellular and Extracellular

2

2 types of Intracellular VBD?

Rickettsia and Erlichiosis

3

2 Types of Rickettsia?

Epidemic typhus and Rocky Mountain Spotted Fever

4

What causes Rocky Mountain spotted fever?

Ticks

5

What causes Epidemic typhus?

Lice

6

What are three extracullar VBD?

1) Lyme disease
2) Relapsing fever
3) Plague

7

What causes Lyme Disease?

Ticks

8

What causes Plague?

Fleas

9

What can be found at the bite location in Rickettsia?

Crusted lesion (eschar)

10

How does one diagnose Rickettsia?

Immunostaining or anti-rickettsial serology

11

Where do Rickettsia mainly multiply??

Small vessel endothelia

12

What are severe manifestations in Rickettsia due to?

Vascular leakage secondary to endothelial cell damage

13

What are the severe manifestations of Rickettsia?

Rash, fever, and CNS manifestations

14

In Rickettsia what does small vessel vasculitis cause?

Microthrombi, focal ischemia, and hemorrhage

15

What does typhus group Rickettsia do to endothelial cells?

Lyses them

16

How does Spotted Fever group Rickettsia spread?

Spreads from cell to cell

17

Risk of Rickettsia spread?

Hypovolemic shock and peripheral edema

18

What type of exotoxins/endotoxins does Rickettsia have?

None

19

While lacking exotoxins/endotoxins what does Rickettsia possess?

LPS which is non-toxic

20

What causes much of the tissue damage in Rickettsia?

Cytotoxic T-cell immune response

21

What do you use for treatment of Rickettsia?

Doxycycline

22

What do Rubella, Rubeola, and Erlichiosis almost never do?

Shock or DIC

23

Which strain of Rickettsia is known as Epidemic Typhus?

Rickettsia Prowazekii

24

How is R. Prowazekii transmitted?

Head lice

25

What does rash look like in Prowazekii?

Moves away from center (centrifugal)

26

In Prowazekii, what happens after rash development?

CNS involvement with apathy, or coma

27

What are the severe clinically findings of severe Prowazekii?

Gangrene of fingers, nose, earlobes, scrotum, penis, vulva

28

What types of ticks cause R. rickettsi?

Dog tick and wood tick

29

What is incubation time for R. rickettsi

7 days

30

What does the rash look like for R. Ricksttsi?

Hemorrhagic rash that extends over entire body including palms and soles, possibly eschar