Flashcards in Infectious Disease 4 Deck (80)
Two main types of vector borne diseases?
Intracellular and Extracellular
2 types of Intracellular VBD?
Rickettsia and Erlichiosis
2 Types of Rickettsia?
Epidemic typhus and Rocky Mountain Spotted Fever
What causes Rocky Mountain spotted fever?
What causes Epidemic typhus?
What are three extracullar VBD?
1) Lyme disease
2) Relapsing fever
What causes Lyme Disease?
What causes Plague?
What can be found at the bite location in Rickettsia?
Crusted lesion (eschar)
How does one diagnose Rickettsia?
Immunostaining or anti-rickettsial serology
Where do Rickettsia mainly multiply??
Small vessel endothelia
What are severe manifestations in Rickettsia due to?
Vascular leakage secondary to endothelial cell damage
What are the severe manifestations of Rickettsia?
Rash, fever, and CNS manifestations
In Rickettsia what does small vessel vasculitis cause?
Microthrombi, focal ischemia, and hemorrhage
What does typhus group Rickettsia do to endothelial cells?
How does Spotted Fever group Rickettsia spread?
Spreads from cell to cell
Risk of Rickettsia spread?
Hypovolemic shock and peripheral edema
What type of exotoxins/endotoxins does Rickettsia have?
While lacking exotoxins/endotoxins what does Rickettsia possess?
LPS which is non-toxic
What causes much of the tissue damage in Rickettsia?
Cytotoxic T-cell immune response
What do you use for treatment of Rickettsia?
What do Rubella, Rubeola, and Erlichiosis almost never do?
Shock or DIC
Which strain of Rickettsia is known as Epidemic Typhus?
How is R. Prowazekii transmitted?
What does rash look like in Prowazekii?
Moves away from center (centrifugal)
In Prowazekii, what happens after rash development?
CNS involvement with apathy, or coma
What are the severe clinically findings of severe Prowazekii?
Gangrene of fingers, nose, earlobes, scrotum, penis, vulva
What types of ticks cause R. rickettsi?
Dog tick and wood tick
What is incubation time for R. rickettsi