Flashcards in Parasite 2 Deck (79)
Tissue response to Helminths and Vermin?
What are the eosinophilic responses?
1) IgE, mast cells
2) Eosiniphilic chemotaxic factors
3) IL-4 and IL-5
Function of IL-4?
Switch to make IgE
Most important fatal helminth disease in humans?
Death from Schistosomes caused by?
Hepatic granulomas and fibrosis
What does Schistosomiasis haematobium in Africa cause?
Hematuria/obstruction of bladder
Predisposition to squamous cell carcinoma of bladder
Where are sporocysts of Schistosomiasis?
Fresh water snails
How do fresh water snails infect humans?
They give rise to cercaria that penetrate through skin
Where do schistosome migrate after skin penetration?
Peripheral vasculature to portal venous system and pelvic venus system
How does tissue react to schistosome eggs?
Granulomas and fibrosis
What completes life cycle of schistosomes?
Eggs shed in feces that hatch in water
What causes the hepatic damage of schistosomes?
Toxic products and cell mediated immunity
Which interleukins result in induction of IgE synthesis, mastocytosis, and eosinophilia?
IL-3, 4, and 5
Resistance to re-infection correlates with what?
Eggs induce lymphocytes to secrete what?
Hallmark of Schistosomiasis?
Hepatic fibrosis out of proportion to parasite injury
Pathology of Schisto?
Calcified pinhead granulomas form around schisto egg
What do schisto granulomas induce?
Macrophages, lymphocytes, neutrophils, and eosinophils
Appearance of portal fibrosis in Schisto?
Pipestem fibrosis results in what in Schisto?
How does one get liver flukes (Clonorchis siensis)?
Eating improperly cooked fish
Where do adult flukes live?
How long do flukes live?
Chronic infection with liver flukes can cause what?
Cholangitis, cholelithiasis, pancreatitis, and cholangiocarcinoma
How does one get Taenia saginata?
Ingestion of undercooked beef
How do you get Taenia solium?
Ingestion of undercooked pork
Which Taenia causes Cysticercosus?
How does T. solium cause cysticercosus?
Eggs ingested, larvae hatch, penetrate gut wall, hematogenous dissemination results in cysts in CNS.
Which cysts in CNS cause problems?
Degenerating cysts. Intact cysts cause little host reaction