Flashcards in Viral Illnesses 3 Deck (42):
What virus cause Polio?
What type of virus is picornaviridae?
Where does the picornaviridae virus infect?
Where does the picornaviridae multiply?
Multiples in the intestinal mucous and lymph nodes
What causes the paralysis in Polio?
Picornaviridae that invades the CNS and replicates in motor neurons of spinal cord/brainstem
What are the cellular receptors of polioviruses?
Members of the immunoglobulin superfamily (Chromosome 19)
What are the two polio vaccines?
Salk and Sabin
Is the salk vaccine attenuated or inactivated?
Inactivated, but requires booster vaccination
IS the sabin vaccine killed or inactivated?
Attenuated, so risk of infection
Benefit of oral sabin vaccine?
Greater duration of immunity
What does the Sabin vaccine produce?
IgA in the GI tract
Rhinovirus binds to what to get access to host?
ICAM-1 found in humans and higher primates on epithelial cells
Where is the rhinovirus infection confined to?
Upper respiratory tract due to cool environemnt
What is the second most common cause of the common cold?
Does coronavirus go to lower respiratory tract?
Primarily upper respiratory, little effect on lower
Where do echovirus and coxsackie virus proliferate?
What is the function of neuraminidase?
Releasing virus from host cell, cleaves silica acid
Function of hemagglutinin?
Binds to silica acid contain proteins and lipids on most cells.
Mediates entry into cell
How are lower respiratory viruses grouped?
Into types A, B, or C based on nucleoprotein
Which is the most dangerous grouping of lower respiratory viruses?
What does group A do?
Major cause of pandemic and epidemic flu infections
What do groups B and C do?
Mostly infect children
What are most deaths due to influenza from?
Secondary bacterial infection due to obstruction
What is croup?
Acute febrile illness with inspiratory stridor, hoarseness, and barking cough
What causes croup?
Parainfluenza type 3
Most common cause of viral pneumonia in children younger than 2 years?
Respiratory syncitial virus
Common cause of acute respiratory disease and pneumonia in military recruits?
Red flag for adenovirus histologically?
Cowdry type A intranuclear inclusion
Most common time for rotavirus to strike?
Time of weaning, due to loss of mothers IgA
What types of hepatitis are there?
A, B, C, Delta agent, and E
How do you get rabies?
Contamination of open wounds or mucous membranes by saliva of infected animals
Is rabies spread person to person?
What is the exception to rabies no being spread person to person?
What causes rabies most in the U.S?
Bites from bats or cats that have bene infected by rabies
What has proved to be the one thing to stop a rabies death?
How does rabies get to CNS?
How long does it take rabies virus to travel up axons?
What is histologically significant to diagnose rabies?
Neri bodies in nerve cells
Only way to truly diagnose rabies?
Direct examination of brain tissue from animal
What do you do for somebody with rabies?
Treat with rabies vaccine and rabies immune gammaglobuin
Who do you give pre-exposure prophylaxis to?
Veterinarians, wildlife workers, people going to endemic areas