Flashcards in Bacteria 2 Deck (80)
2 examples of common upper respiratory infections caused by normal flora?
1) Ottis media
What causes upper respiratory infections via normal flora?
Blockage of sinus ostia, estachian tube by virally induced or allergic inflammation
What causes invasive Upper respiratory disease in neonates?
E. coli and Group B Strep
What causes IURD in children 1-5?
H. influenzae type B
What cause IURD in adolscents and young adults?
What causes IURD in all age groups?
What is the key to pathogenicity for bacteria?
Where does the pathogenesis begin?
Upper respiratory infection
What happens after the initial Upper respiratory infection?
Invasion of bacteria into deep tissues and bloodstream
What happens when the bacteria is disseminated in the body?
What leads to vascular leakage?
Endothelial and macrophage activation by LPS
Vascular leakage leads to what?
Disseminated intravascular coagulation (DIC)
Infections with encapsulated organisms require what that Staph and strep infections don't?
Antibodies or complement
What is a splenic condition that increases susceptibility to encapsulated organisms?
Where is Pneumococcus found?
Normal Upper respiratory flora
What does Pneumococcus look like?
Gram + diplococcus
Pneumococcus virulence factors?
Capsule and PspC (Pneumococcal surface protein C)
Disease caused by Pneumococcus?
Sepsis and meningitis
Where is N. meningitidis?
What does N. meningitides look like?
Gram -, diplococcus
Virulence factors of N. meningitides?
Capsule and LPS
Disease caused by N. meningitides?
DIC, sepsis, meningitis
Where is N. gonorrhea found?
What does N. gonorrhea look like?
Gram - diplococcus
Virulence factors of N. gonorrhea?
Capsule and LOS
Diseases of N. gonorrhea?
Where is H. influenza found?
Normal flora, type B exogenous
What does H. influenza look like?
Gram - pleomorphic
Virulence factors of H. influenza?
Capsule and LPS