Flashcards in Bacteria 2 Deck (80)
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1
2 examples of common upper respiratory infections caused by normal flora?
1) Ottis media
2) sinusitis
2
What causes upper respiratory infections via normal flora?
Blockage of sinus ostia, estachian tube by virally induced or allergic inflammation
3
What causes invasive Upper respiratory disease in neonates?
E. coli and Group B Strep
4
What causes IURD in children 1-5?
H. influenzae type B
5
What cause IURD in adolscents and young adults?
N. meningitidis
6
What causes IURD in all age groups?
Strep pneumoniae
7
What is the key to pathogenicity for bacteria?
Encapsulation
8
Where does the pathogenesis begin?
Upper respiratory infection
9
What happens after the initial Upper respiratory infection?
Invasion of bacteria into deep tissues and bloodstream
10
What happens when the bacteria is disseminated in the body?
Bacteremia
11
What leads to vascular leakage?
Endothelial and macrophage activation by LPS
12
Vascular leakage leads to what?
Disseminated intravascular coagulation (DIC)
13
Infections with encapsulated organisms require what that Staph and strep infections don't?
Antibodies or complement
14
What is a splenic condition that increases susceptibility to encapsulated organisms?
Asplenia
15
Where is Pneumococcus found?
Normal Upper respiratory flora
16
What does Pneumococcus look like?
Gram + diplococcus
17
Pneumococcus virulence factors?
Capsule and PspC (Pneumococcal surface protein C)
18
Disease caused by Pneumococcus?
Sepsis and meningitis
19
Where is N. meningitidis?
Exogenous
20
What does N. meningitides look like?
Gram -, diplococcus
21
Virulence factors of N. meningitides?
Capsule and LPS
22
Disease caused by N. meningitides?
DIC, sepsis, meningitis
23
Where is N. gonorrhea found?
Exogenous
24
What does N. gonorrhea look like?
Gram - diplococcus
25
Virulence factors of N. gonorrhea?
Capsule and LOS
26
Diseases of N. gonorrhea?
Septic arthritis
27
Where is H. influenza found?
Normal flora, type B exogenous
28
What does H. influenza look like?
Gram - pleomorphic
29
Virulence factors of H. influenza?
Capsule and LPS
30
