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Flashcards in Bacteria 2 Deck (80)
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1

2 examples of common upper respiratory infections caused by normal flora?

1) Ottis media
2) sinusitis

2

What causes upper respiratory infections via normal flora?

Blockage of sinus ostia, estachian tube by virally induced or allergic inflammation

3

What causes invasive Upper respiratory disease in neonates?

E. coli and Group B Strep

4

What causes IURD in children 1-5?

H. influenzae type B

5

What cause IURD in adolscents and young adults?

N. meningitidis

6

What causes IURD in all age groups?

Strep pneumoniae

7

What is the key to pathogenicity for bacteria?

Encapsulation

8

Where does the pathogenesis begin?

Upper respiratory infection

9

What happens after the initial Upper respiratory infection?

Invasion of bacteria into deep tissues and bloodstream

10

What happens when the bacteria is disseminated in the body?

Bacteremia

11

What leads to vascular leakage?

Endothelial and macrophage activation by LPS

12

Vascular leakage leads to what?

Disseminated intravascular coagulation (DIC)

13

Infections with encapsulated organisms require what that Staph and strep infections don't?

Antibodies or complement

14

What is a splenic condition that increases susceptibility to encapsulated organisms?

Asplenia

15

Where is Pneumococcus found?

Normal Upper respiratory flora

16

What does Pneumococcus look like?

Gram + diplococcus

17

Pneumococcus virulence factors?

Capsule and PspC (Pneumococcal surface protein C)

18

Disease caused by Pneumococcus?

Sepsis and meningitis

19

Where is N. meningitidis?

Exogenous

20

What does N. meningitides look like?

Gram -, diplococcus

21

Virulence factors of N. meningitides?

Capsule and LPS

22

Disease caused by N. meningitides?

DIC, sepsis, meningitis

23

Where is N. gonorrhea found?

Exogenous

24

What does N. gonorrhea look like?

Gram - diplococcus

25

Virulence factors of N. gonorrhea?

Capsule and LOS

26

Diseases of N. gonorrhea?

Septic arthritis

27

Where is H. influenza found?

Normal flora, type B exogenous

28

What does H. influenza look like?

Gram - pleomorphic

29

Virulence factors of H. influenza?

Capsule and LPS

30

Disease caused by H. Influenzae?

Sepsis and meningitis