Flashcards in Infectious Disease 5 Deck (45):
How is anthrax transmitted?
Animals/contact with animals (sheep and goats)
How is anthrax weaponized?
Powder form that is inhaled
How does Anthrax present cutaneously?
Hemmorrhagic pustule that turns into a black eschar
How does pulmonary disease involving anthrax present?
Pneumonia with serofibrinous exudate and septicemia
How do you control for anthrax?
Vaccine, penicillin, and doxycycline
What gives mycobacterium tuberculosis resistance to intracellular killing?
Histologic hallmark of Mycobacterium TB?
What endotoxins/exotoxins/histolytic enzymes are involved in TB?
What type of hypersensitivity reaction is TB?
What is a granuloma?
Inability of macrophage to kill bacteria that results in persistent infection
What results in secretion of interferon gamma?
Development of TH1 cells
What does TNF result in?
Chemotaxis and collection of monocytes
What does interferon gamma result in?
Aggregation of epithelia macrophages
What does granuloma formation cause?
Chronic inflammation, fibrosis, and caseous necrosis
What is a Ghon complex?
Primary lung lesion with caseating granulomas in draining lymph nodes
What is secondary TB?
Re-activation/re-infection in previously sensitized individual
Tertiary TB leads to what>
Empyema, bacteremia, and extension to other parts of lung
What is Quanti-feron test for TB?
In vitro measure of interferon in response to M.TB
Where does Leprosy infect?
Skin and nerves
Why does Leprosy target skin and nerves?
They are the coolest parts of the body
How does tuberculoid leprosy appear?
How does lepromatous form appear?
Foam cells, lack of TH1 immunity, proliferation in macrophages
Which form of leprosy is contagious?
Syphillis has an outer health that serves to do what?
Cause persistence by hiding antigens
How is Syphillis spread>
Transplacental and sexually
In the Syphillis nonspecific antibody test what are you looking for?
What are common false positives in Syphillis antibody tests?
Mono and Lupus
What is present during primary stage of Syphilis?
No antibodies, organism is present
What is present during secondary stage of Syphilis?
Both antibodies and organism are present
What is present for 3rd stage of syphilis?
Antibodies present, no organisms though
What are Syphilis chancres infiltrated with?
What is central to pathology of all lesions in Syphilis?
Where does primary Syphilis develop?
Hard chancre at site of spirochete invasion
What are the elevated plaques by the penis/vulva called in secondary syphilis?
How long until secondary stage shows up for syphilis>
2-10 weeks after primary
How long until tertiary symptoms of Syphilus show?
5 years or more
Most commonly affected system from tertiary syphilis?
What is Charcot's joint?
Sensory loss, can't feel feet.
What will the CSF look like for Syphilis in 3rd stage?
Increased WBC count, increased protein, decreased glucose
Saber shin, saddle nose, and Hutchinson teeth from what?
Late abortionCongenital infection with Syphilis
What type of abortion can Syphilis cause?
Anthrax infections associated with what?
What causes death in Anthrax?
TB intra or extracellular?