Infectious Disease 5 Flashcards Preview

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Flashcards in Infectious Disease 5 Deck (45):
1

How is anthrax transmitted?

Animals/contact with animals (sheep and goats)

2

How is anthrax weaponized?

Powder form that is inhaled

3

How does Anthrax present cutaneously?

Hemmorrhagic pustule that turns into a black eschar

4

How does pulmonary disease involving anthrax present?

Pneumonia with serofibrinous exudate and septicemia

5

How do you control for anthrax?

Vaccine, penicillin, and doxycycline

6

What gives mycobacterium tuberculosis resistance to intracellular killing?

Glycolipids

7

Histologic hallmark of Mycobacterium TB?

Caseating granulomas

8

What endotoxins/exotoxins/histolytic enzymes are involved in TB?

None

9

What type of hypersensitivity reaction is TB?

4

10

What is a granuloma?

Inability of macrophage to kill bacteria that results in persistent infection

11

What results in secretion of interferon gamma?

Development of TH1 cells

12

What does TNF result in?

Chemotaxis and collection of monocytes

13

What does interferon gamma result in?

Aggregation of epithelia macrophages

14

What does granuloma formation cause?

Chronic inflammation, fibrosis, and caseous necrosis

15

What is a Ghon complex?

Primary lung lesion with caseating granulomas in draining lymph nodes

16

What is secondary TB?

Re-activation/re-infection in previously sensitized individual

17

Tertiary TB leads to what>

Empyema, bacteremia, and extension to other parts of lung

18

What is Quanti-feron test for TB?

In vitro measure of interferon in response to M.TB

19

Where does Leprosy infect?

Skin and nerves

20

Why does Leprosy target skin and nerves?

They are the coolest parts of the body

21

How does tuberculoid leprosy appear?

Granulomatous

22

How does lepromatous form appear?

Foam cells, lack of TH1 immunity, proliferation in macrophages

23

Which form of leprosy is contagious?

Lepromatous

24

Syphillis has an outer health that serves to do what?

Cause persistence by hiding antigens

25

How is Syphillis spread>

Transplacental and sexually

26

In the Syphillis nonspecific antibody test what are you looking for?

Cardiolipin

27

What are common false positives in Syphillis antibody tests?

Mono and Lupus

28

What is present during primary stage of Syphilis?

No antibodies, organism is present

29

What is present during secondary stage of Syphilis?

Both antibodies and organism are present

30

What is present for 3rd stage of syphilis?

Antibodies present, no organisms though

31

What are Syphilis chancres infiltrated with?

TH1 cells

32

What is central to pathology of all lesions in Syphilis?

Endarteritis

33

Where does primary Syphilis develop?

Hard chancre at site of spirochete invasion

34

What are the elevated plaques by the penis/vulva called in secondary syphilis?

Condylomata Lata

35

How long until secondary stage shows up for syphilis>

2-10 weeks after primary

36

How long until tertiary symptoms of Syphilus show?

5 years or more

37

Most commonly affected system from tertiary syphilis?

Cardiovascular

38

What is Charcot's joint?

Sensory loss, can't feel feet.

39

What will the CSF look like for Syphilis in 3rd stage?

Increased WBC count, increased protein, decreased glucose

40

Saber shin, saddle nose, and Hutchinson teeth from what?

Late abortionCongenital infection with Syphilis

41

What type of abortion can Syphilis cause?

Late

42

Anthrax infections associated with what?

Leukopenia

43

What causes death in Anthrax?

Electrolyte imbalance
Hemoconcentration
DIC

44

TB intra or extracellular?

Intra

45

Key feature of Leprosy?

Anesthesia of skin