Flashcards in Mycoplasma/Mycobacteria/Leprosy Deck (29)
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1
Tiniest free-living organisms known?
Mycoplasma
2
Mycoplasma intra or extra cellular?
Extracellular
3
Main (2) disease Mycoplasma causes?
Pneumonia
Urethritis
4
How does Mycoplasma pneumonia usually present?
"Walking pneumonia"
5
What is Mycoplasma pneumonia associated with the production of?
Cold agglutinin
6
What does "acid fast" mean?
Retains the red dye carbofuchsin after rinsing with acid solvents
7
Is Mycobacteria acid fast?
Yes
8
Virulence factors of mycobacteria?
Glycolipids that promote resistance to intracellular killing
Inhibit interferon activation of macrophages
Prevention of phase-lysosomal membrane fusion
Stimulate destructive cell mediated inflammatory injury
9
Histologic hallmark of Tuberculosis?
Caseating granulomas
10
How is TB transmitted?
Sustained contact
11
Hon focus found where?
Lower part of upper lobes or upper part of lower lobes unilaterally
12
How do most cases of TB pan out?
Fibrosis and calcification show up but rarely progress to disease
13
Best test for recent exposure?
PPD
14
BCG vaccine should not be considered responsible for PPD reaction of what size?
>1.0cm
15
Atypical Mycobacterial infection that causes pulmonary disease?
M. kansasii
M. avium intracellulare
16
M. avium intracellular associated with what disease?
AIDS
Chronic bronchitis
Emphysema
17
What is Leprosy?
Obligate intracellular mycobacterium
18
How is leprosy spread?
Respiratory aerosols
19
Where is leprosy limited to?
Skin and nerves due to cool temp
20
Where does leprosy start?
Respiratory tract where it disseminates through blood to skin
21
Key feature of Leprosy?
Anesthesia of skin
22
What determines form of leprosy?
Degree of cell mediated immunity
23
Tuberculoid leprosy forms what?
Granulomas
24
Tuberculoid leprosy associated with strong what?
TH1 responses
25
Tuberculoid leprosy mediated by what?
Release of IL-2 and IFN
26
Lepromatous leprosy associated with what?
Lack of TH-1 Helper response
Proliferation of organisms in macrophages
27
Is there granuloma formation in Lepromatous leprosy?
No
28
Lepromatous leprosy lesions filled with what?
Lipid laden macrophages containing many bacteria
29
