Mycoplasma/Mycobacteria/Leprosy Flashcards Preview

Pathology > Mycoplasma/Mycobacteria/Leprosy > Flashcards

Flashcards in Mycoplasma/Mycobacteria/Leprosy Deck (29):
1

Tiniest free-living organisms known?

Mycoplasma

2

Mycoplasma intra or extra cellular?

Extracellular

3

Main (2) disease Mycoplasma causes?

Pneumonia
Urethritis

4

How does Mycoplasma pneumonia usually present?

"Walking pneumonia"

5

What is Mycoplasma pneumonia associated with the production of?

Cold agglutinin

6

What does "acid fast" mean?

Retains the red dye carbofuchsin after rinsing with acid solvents

7

Is Mycobacteria acid fast?

Yes

8

Virulence factors of mycobacteria?

Glycolipids that promote resistance to intracellular killing
Inhibit interferon activation of macrophages
Prevention of phase-lysosomal membrane fusion
Stimulate destructive cell mediated inflammatory injury

9

Histologic hallmark of Tuberculosis?

Caseating granulomas

10

How is TB transmitted?

Sustained contact

11

Hon focus found where?

Lower part of upper lobes or upper part of lower lobes unilaterally

12

How do most cases of TB pan out?

Fibrosis and calcification show up but rarely progress to disease

13

Best test for recent exposure?

PPD

14

BCG vaccine should not be considered responsible for PPD reaction of what size?

>1.0cm

15

Atypical Mycobacterial infection that causes pulmonary disease?

M. kansasii
M. avium intracellulare

16

M. avium intracellular associated with what disease?

AIDS
Chronic bronchitis
Emphysema

17

What is Leprosy?

Obligate intracellular mycobacterium

18

How is leprosy spread?

Respiratory aerosols

19

Where is leprosy limited to?

Skin and nerves due to cool temp

20

Where does leprosy start?

Respiratory tract where it disseminates through blood to skin

21

Key feature of Leprosy?

Anesthesia of skin

22

What determines form of leprosy?

Degree of cell mediated immunity

23

Tuberculoid leprosy forms what?

Granulomas

24

Tuberculoid leprosy associated with strong what?

TH1 responses

25

Tuberculoid leprosy mediated by what?

Release of IL-2 and IFN

26

Lepromatous leprosy associated with what?

Lack of TH-1 Helper response
Proliferation of organisms in macrophages

27

Is there granuloma formation in Lepromatous leprosy?

No

28

Lepromatous leprosy lesions filled with what?

Lipid laden macrophages containing many bacteria

29

Which leprosy is the contagious versions?

Lepromatous