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Flashcards in HIV 3 Deck (22):
1

What is "the window" for seroconversion in HIV?

6-12 weeks

2

What is diagnosis based on?

Antibody presence to multiple HIV antigens such as gp120, gp41, gp 24

3

What is used in combination with serology?

WB test

4

What constitutes undetectable levels of viral RNA?

50 copies per ml

5

Increase in RNA levels indicates what?

Progression of disease

6

Strongest indicator of disease progression?

CD4 counts

7

Pattern of lymph nodes after chronic infection?

"Burned out with loss of lymphoid elements

8

HIV infection of CNS will show inflammatory infiltrate with what?

Microglial nodules and multinucleated giant cells

9

What forms Karposi's sarcoma?

Proliferating mesenchymal spindle cells that form blood vessels

10

Why is serology not helpful in later stages of AIDs?

Patient cannot mount antibody response

11

Why is it common that patients show atypical symptoms when they have an infection?

Immune system is messed up

12

What symptoms at time of transmission?

Fever, malaise, and rash

13

Which repeated infections typically present?

Pneumocystis carinii, Mycobacterium avium, and cytomegalovirus

14

What can occur if patients suffer from HIV infection of microglial cells?

CNS dementia

15

What opportunistic viral infections are at risk for reinfection?

CMV, Herpes, Zoster

16

What opportunistic infections are at risk for latent reactivation?

Toxoplasmosis, TB, herpes zoster

17

Karposi's sarcoma associated with what infection?

HHV8

18

Non-Hodgkin Lymphoma associated with what?

B-cell origin

19

Invasive carcinoma of uternine cervix associated with what?

HPV infection

20

Danger of antibodies and HIV?

Antibodies may allow virus into dendritic cells

21

what is the major focus of HIV erradication efforts?

Prevention

22

Cause of current HAART therapy complications attributed to?

Persistent inflammation and/or T-Cell dysfunction