Flashcards in HIV 3 Deck (22):
1
What is "the window" for seroconversion in HIV?
6-12 weeks
2
What is diagnosis based on?
Antibody presence to multiple HIV antigens such as gp120, gp41, gp 24
3
What is used in combination with serology?
WB test
4
What constitutes undetectable levels of viral RNA?
50 copies per ml
5
Increase in RNA levels indicates what?
Progression of disease
6
Strongest indicator of disease progression?
CD4 counts
7
Pattern of lymph nodes after chronic infection?
"Burned out with loss of lymphoid elements
8
HIV infection of CNS will show inflammatory infiltrate with what?
Microglial nodules and multinucleated giant cells
9
What forms Karposi's sarcoma?
Proliferating mesenchymal spindle cells that form blood vessels
10
Why is serology not helpful in later stages of AIDs?
Patient cannot mount antibody response
11
Why is it common that patients show atypical symptoms when they have an infection?
Immune system is messed up
12
What symptoms at time of transmission?
Fever, malaise, and rash
13
Which repeated infections typically present?
Pneumocystis carinii, Mycobacterium avium, and cytomegalovirus
14
What can occur if patients suffer from HIV infection of microglial cells?
CNS dementia
15
What opportunistic viral infections are at risk for reinfection?
CMV, Herpes, Zoster
16
What opportunistic infections are at risk for latent reactivation?
Toxoplasmosis, TB, herpes zoster
17
Karposi's sarcoma associated with what infection?
HHV8
18
Non-Hodgkin Lymphoma associated with what?
B-cell origin
19
Invasive carcinoma of uternine cervix associated with what?
HPV infection
20
Danger of antibodies and HIV?
Antibodies may allow virus into dendritic cells
21
what is the major focus of HIV erradication efforts?
Prevention
22