Viral illness 4 Flashcards Preview

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Flashcards in Viral illness 4 Deck (46):
1

Herpes simplex virus 1 is what?

Cold sores

2

Herpes simplex virus 2 is what?

Genital herpes

3

What does herpes simplex virus look like?

Large, encapsulated virus with ds DNA genome

4

Where does HSV remain latent?

Nerve cells

5

What does HSV synthesize while in latent state?

Nothing

6

What will you find if you scrape the lesion of HSV and look at it histologically?

Inclusion bearing multinucleate syncytial (giant cells)

7

Pattern of HSV lesion formation?

Bilaterally and ignoring dermatomes

8

Major cause of cornea blindness?

HSV-1

9

Fatal sporadic encephalitis caused by?

HSV-1

10

How is infectious mononucleosis transmitted?

Close contact, saliva by kissing

11

Where does Epstein Barr bind to to cause infectious mono?

Complement receptor on epithelial cells and B cells

12

Where does Epstein barr spread to?

B-lymphoid tissues

13

Which cells on a smear appear atypical during an Epstein Barr virus infection?

T-cells

14

What test do you use for Mono?

Monospot

15

What is used in mono spot test?

Human anti-sheep RBCs agglutination

16

What will you see in blood of EBV patient?

Atypical lymphocytes (Anti-EBV T cells)

17

Biggest danger in EBV?

Spleen rupture

18

What is EBV common confused with?

Hodgkin's disease

19

Diagnosis of EBV dependent on what?

Atypical lymphocytes
Positive heterophile reaction
Specific antibodies for EBV antigens

20

Are the heterophiles antibodies specific for EBV?

No

21

What causes X-linked lymphoproliferative disease?

Absence of gene called SAP (signaling lymphocyte activation molecule associated protein)

22

CMV is part of what important mnemonic?

TORCHS

23

In CMV what is important in diagnosis?

Urine sediment helps

24

CMV associated with what from latent infection of leukocytes>

Reactivation of viral infection

25

CMV infection in AIDs patients almost always accompanied by what infection?

Pneumocystis carinii

26

How is HPV transmitted?

Direct contact

27

Non-neoplastic strains of HPV associated with what?

Koilocytosis

28

Neoplastic strains of HPV associated with what?

Viral intergration within the DNA

29

Verruca vulgaris is known as whaT?

Common warts

30

Difference between condyloma accuminatum vs condyloma late?

Late are plaques from syphilis
Accuminatum are genital warts

31

Other Neoplastic viruses?

HHV8 (Karposi)
Hep B
Hep C

32

Only vector for Ebola?

Human

33

How does Ebola spread?

Human to human

34

What is transmission for Ebola?

Nosocomial

35

Where in the body does ebola hit?

Liver, viseral organ necrosis

36

How is Hanta virus spread?

Human through rodent urine or feces

37

How does Hanta virus present?

Acute hemorrhagic pulmonary syndrome

38

Where does Hanta virus present?

Southwest (4 corners area)

39

Where is Dengue?

Tropics and Africa

40

Which mosquito spreads Dengue?

Aedes mosquito

41

Dengue hemorrhagic fever is also known as what?

Breakbone fever

42

Rare symptoms of Dengue?

Hemorrhagic phenomena, thrombocytopenia, dengue shock syndrome

43

How does West Nile Virus spread?

Transmitted by mosquitoes to birds and mammals

44

What is the major reservoir for West nile?

Birds
Humans are accidental

45

Who is at risk for West Nile?

Elderly and immunocompromised

46

Biggest danger of West Nile?

CNS symptoms involving meningitis, encephalitis, and meningoencephalitis