Viral illness 4

Question 1

Herpes simplex virus 1 is what?

Answer 1

Cold sores

Question 2

Herpes simplex virus 2 is what?

Answer 2

Genital herpes

Question 3

What does herpes simplex virus look like?

Answer 3

Large, encapsulated virus with ds DNA genome

Question 4

Where does HSV remain latent?

Answer 4

Nerve cells

Question 5

What does HSV synthesize while in latent state?

Answer 5

Nothing

Question 6

What will you find if you scrape the lesion of HSV and look at it histologically?

Answer 6

Inclusion bearing multinucleate syncytial (giant cells)

Question 7

Pattern of HSV lesion formation?

Answer 7

Bilaterally and ignoring dermatomes

Question 8

Major cause of cornea blindness?

Answer 8

HSV-1

Question 9

Fatal sporadic encephalitis caused by?

Answer 9

HSV-1

Question 10

How is infectious mononucleosis transmitted?

Answer 10

Close contact, saliva by kissing

Question 11

Where does Epstein Barr bind to to cause infectious mono?

Answer 11

Complement receptor on epithelial cells and B cells

Question 12

Where does Epstein barr spread to?

Answer 12

B-lymphoid tissues

Question 13

Which cells on a smear appear atypical during an Epstein Barr virus infection?

Answer 13

T-cells

Question 14

What test do you use for Mono?

Answer 14

Monospot

Question 15

What is used in mono spot test?

Answer 15

Human anti-sheep RBCs agglutination

Question 16

What will you see in blood of EBV patient?

Answer 16

Atypical lymphocytes (Anti-EBV T cells)

Question 17

Biggest danger in EBV?

Answer 17

Spleen rupture

Question 18

What is EBV common confused with?

Answer 18

Hodgkin’s disease

Question 19

Diagnosis of EBV dependent on what?

Answer 19

Atypical lymphocytes
Positive heterophile reaction
Specific antibodies for EBV antigens

Question 20

Are the heterophiles antibodies specific for EBV?

Answer 20

No

Question 21

What causes X-linked lymphoproliferative disease?

Answer 21

Absence of gene called SAP (signaling lymphocyte activation molecule associated protein)

Question 22

CMV is part of what important mnemonic?

Answer 22

TORCHS

Question 23

In CMV what is important in diagnosis?

Answer 23

Urine sediment helps

Question 24

CMV associated with what from latent infection of leukocytes>

Answer 24

Reactivation of viral infection

Question 25

CMV infection in AIDs patients almost always accompanied by what infection?

Answer 25

Pneumocystis carinii

Question 26

How is HPV transmitted?

Answer 26

Direct contact

Question 27

Non-neoplastic strains of HPV associated with what?

Answer 27

Koilocytosis

Question 28

Neoplastic strains of HPV associated with what?

Answer 28

Viral intergration within the DNA

Question 29

Verruca vulgaris is known as whaT?

Answer 29

Common warts

Question 30

Difference between condyloma accuminatum vs condyloma late?

Answer 30

Late are plaques from syphilis | Accuminatum are genital warts

Question 31

Other Neoplastic viruses?

Answer 31

HHV8 (Karposi) Hep B Hep C

Question 32

Only vector for Ebola?

Answer 32

Human

Question 33

How does Ebola spread?

Answer 33

Human to human

Question 34

What is transmission for Ebola?

Answer 34

Nosocomial

Question 35

Where in the body does ebola hit?

Answer 35

Liver, viseral organ necrosis

Question 36

How is Hanta virus spread?

Answer 36

Human through rodent urine or feces

Question 37

How does Hanta virus present?

Answer 37

Acute hemorrhagic pulmonary syndrome

Question 38

Where does Hanta virus present?

Answer 38

Southwest (4 corners area)

Question 39

Where is Dengue?

Answer 39

Tropics and Africa

Question 40

Which mosquito spreads Dengue?

Answer 40

Aedes mosquito

Question 41

Dengue hemorrhagic fever is also known as what?

Answer 41

Breakbone fever

Question 42

Rare symptoms of Dengue?

Answer 42

Hemorrhagic phenomena, thrombocytopenia, dengue shock syndrome

Question 43

How does West Nile Virus spread?

Answer 43

Transmitted by mosquitoes to birds and mammals

Question 44

What is the major reservoir for West nile?

Answer 44

Birds | Humans are accidental

Question 45

Who is at risk for West Nile?

Answer 45

Elderly and immunocompromised

Question 46

Biggest danger of West Nile?

Answer 46

CNS symptoms involving meningitis, encephalitis, and meningoencephalitis