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Flashcards in Viral illness 1 Deck (35):
1

How are viruses transmitted?

Secretions or cells

2

How do viruses damage the host cell?

Entering the cell and replicating at the host expense

3

How does Epstein Barr Virus attach to host cell?

Complement CD21 receptor on macrophages

4

How does Rabies attach to host cell?

Acetylcholine receptor

5

How does Rhinovirus attach to the host cell?

ICAM-1

6

What special enzymes or promoter element is required for JC virus to get in?

Oligodendrocytes

7

Hallmark of viruses in infected cells?

Morphologic alterations

8

What host immune responses will be used to deal with viruses?

Antibody and cell mediated responses

9

Function of antibodies?

Prevent viremia and prevent re-infection

10

How does the antibody neutralize the virus?

Prevents attachment
Interferes with viral uncoating

11

How can antibodies be used in disease states?

Glomerulonephritis
Arthralgias
Enhance cell uptake and promote infection

12

In the cell mediated response how does the process work?

Mediated by CD8, needs CD4 for initial reaction

13

Which MHC class does CD8 target?

1

14

NK cells go after what?

Virally infected cells not displaying MHC 1

15

Cell mediated response releases interferon y (gamma), what's it do?

Inhibits RNA translation which hurts viruses more than us

16

Interferons alpha and beta do what?

Activation of antiviral responses

17

Two main patterns of viral infection?

Local and Distant

18

Incubation time for local viral illness?

Days

19

Incubation time for distant viral illness?

Weeks

20

Lesions in local viral illness are where?

Site of entry

21

Lesions in distant viral illness involve what?

Immune mediated damage

22

What 3 features determine pathology of virus?

1) Distribution of organism
2) Cytopathic features of virus
3) Host immune reaction

23

What is characteristic of cytopathic features

Inclusion bodies

24

In what viral illness will I see inclusion bodies in the nucleus?

Herpes

25

In what viral illness will I see inclusion bodies in the cytoplasm?

Rabies (negri bodies)

26

In what viral illness will I see inclusion bodies in nucleus and cytoplasm?

CMV

27

Difference between bacterial and viral infection?

No abscesses

28

Councilman bodies found in what?

Hepatitis apoptotic cells

29

Warthin-Finkeldey indicated by?

Measles giant cells

30

Ground glass cytoplasm found in?

Hepatitis

31

Kailocytosis indicative of what?

Papilloma virus

32

What is seen in CMV?

Distinct intranuclear and ill defined cytoplasmic inclusions

33

What is seen in herpes/varicella?

Cowdry type A intranuclear bodies

34

What is seen in Rabies?

Negri bodies

35

What is seen in adenovirus?

Smudge cells and Cowdry type A intanuclear inclusion bodies