Flashcards in Viral illness 1 Deck (35):
How are viruses transmitted?
Secretions or cells
How do viruses damage the host cell?
Entering the cell and replicating at the host expense
How does Epstein Barr Virus attach to host cell?
Complement CD21 receptor on macrophages
How does Rabies attach to host cell?
How does Rhinovirus attach to the host cell?
What special enzymes or promoter element is required for JC virus to get in?
Hallmark of viruses in infected cells?
What host immune responses will be used to deal with viruses?
Antibody and cell mediated responses
Function of antibodies?
Prevent viremia and prevent re-infection
How does the antibody neutralize the virus?
Interferes with viral uncoating
How can antibodies be used in disease states?
Enhance cell uptake and promote infection
In the cell mediated response how does the process work?
Mediated by CD8, needs CD4 for initial reaction
Which MHC class does CD8 target?
NK cells go after what?
Virally infected cells not displaying MHC 1
Cell mediated response releases interferon y (gamma), what's it do?
Inhibits RNA translation which hurts viruses more than us
Interferons alpha and beta do what?
Activation of antiviral responses
Two main patterns of viral infection?
Local and Distant
Incubation time for local viral illness?
Incubation time for distant viral illness?
Lesions in local viral illness are where?
Site of entry
Lesions in distant viral illness involve what?
Immune mediated damage
What 3 features determine pathology of virus?
1) Distribution of organism
2) Cytopathic features of virus
3) Host immune reaction
What is characteristic of cytopathic features
In what viral illness will I see inclusion bodies in the nucleus?
In what viral illness will I see inclusion bodies in the cytoplasm?
Rabies (negri bodies)
In what viral illness will I see inclusion bodies in nucleus and cytoplasm?
Difference between bacterial and viral infection?
Councilman bodies found in what?
Hepatitis apoptotic cells
Warthin-Finkeldey indicated by?
Measles giant cells
Ground glass cytoplasm found in?
Kailocytosis indicative of what?
What is seen in CMV?
Distinct intranuclear and ill defined cytoplasmic inclusions
What is seen in herpes/varicella?
Cowdry type A intranuclear bodies
What is seen in Rabies?