Flashcards in Viral illness 1 Deck (35):
1
How are viruses transmitted?
Secretions or cells
2
How do viruses damage the host cell?
Entering the cell and replicating at the host expense
3
How does Epstein Barr Virus attach to host cell?
Complement CD21 receptor on macrophages
4
How does Rabies attach to host cell?
Acetylcholine receptor
5
How does Rhinovirus attach to the host cell?
ICAM-1
6
What special enzymes or promoter element is required for JC virus to get in?
Oligodendrocytes
7
Hallmark of viruses in infected cells?
Morphologic alterations
8
What host immune responses will be used to deal with viruses?
Antibody and cell mediated responses
9
Function of antibodies?
Prevent viremia and prevent re-infection
10
How does the antibody neutralize the virus?
Prevents attachment
Interferes with viral uncoating
11
How can antibodies be used in disease states?
Glomerulonephritis
Arthralgias
Enhance cell uptake and promote infection
12
In the cell mediated response how does the process work?
Mediated by CD8, needs CD4 for initial reaction
13
Which MHC class does CD8 target?
1
14
NK cells go after what?
Virally infected cells not displaying MHC 1
15
Cell mediated response releases interferon y (gamma), what's it do?
Inhibits RNA translation which hurts viruses more than us
16
Interferons alpha and beta do what?
Activation of antiviral responses
17
Two main patterns of viral infection?
Local and Distant
18
Incubation time for local viral illness?
Days
19
Incubation time for distant viral illness?
Weeks
20
Lesions in local viral illness are where?
Site of entry
21
Lesions in distant viral illness involve what?
Immune mediated damage
22
What 3 features determine pathology of virus?
1) Distribution of organism
2) Cytopathic features of virus
3) Host immune reaction
23
What is characteristic of cytopathic features
Inclusion bodies
24
In what viral illness will I see inclusion bodies in the nucleus?
Herpes
25
In what viral illness will I see inclusion bodies in the cytoplasm?
Rabies (negri bodies)
26
In what viral illness will I see inclusion bodies in nucleus and cytoplasm?
CMV
27
Difference between bacterial and viral infection?
No abscesses
28
Councilman bodies found in what?
Hepatitis apoptotic cells
29
Warthin-Finkeldey indicated by?
Measles giant cells
30
Ground glass cytoplasm found in?
Hepatitis
31
Kailocytosis indicative of what?
Papilloma virus
32
What is seen in CMV?
Distinct intranuclear and ill defined cytoplasmic inclusions
33
What is seen in herpes/varicella?
Cowdry type A intranuclear bodies
34
What is seen in Rabies?
Negri bodies
35