JVD 2019 # 1 Clinicopathological Features, Risk Factors and Predispositions, and Response to Treatment of Eosinophilic Oral Disease in 24 Dogs (2000-2016) Danielle Mendelsohn

Question 1

Top breeds represented

Answer 1

Cavalier King Charles spaniel (16.7%), Labrador retriever (12.5%), and West Highland white terrier (12.5%) of 15 breeds total.
Previous studies indicate a possible genetic component in Siberian huskies, greyhounds, and Cavalier King Charles spaniels.

Question 2

location of lesions

Answer 2

palate (n=17, 65.4%), tongue (n=7, 26.9%), and other oral locations (n=2, 7.7%) 2 dogs had lesion in multiple locations

Question 3

Statistically significant assoc between lesion location & body weight

Answer 3

palatal and tongue lesions were more likely in smaller dogs, whereas lesions in the other category [lip or mucosa] were more likely in larger dogs

Question 4

Correlation in lesion location and resolution

Answer 4

all dogs with palatal lesions became asymptomatic at their last recheck), and resolution and the use of antibiotics plus prednisone (greater likelihood of resolution without the use of this combination

Question 5

Asymptomatic dog resolution?

Answer 5

Seventy percent of asymptomatic dogs resolved without medication or with allergen therapy alone, suggesting that asymptomatic dogs may respond well to conservative management.

Question 6

What is eosinophilic stomatitis or eosinophilic granuloma?

Answer 6

Eosinophilic granuloma complex is a general term used to encompass a variety of cutaneous, mucocutaneous, and oral cavity lesions in the dog and cat.
hese conditions are considered to be rare in the dog and are typically described as nodules or plaques on the soft palate or vegetative masses on the tongue. Less frequently, lesions are reported on the ventral abdomen, prepuce, digits, flanks, cheeks, external ear canal, nasal plane, and trachea.

Question 7

Type 1 hypersensitivity reaction

Answer 7

Cell-mediated. Theory supported by predominance of eosinophils in these lesions and positive response to steroid tx

Question 8

Typical histopath characteristics of eosinophilic granuloma

Answer 8

predominantly eosinophilic inflammatory infiltrate with varying numbers of mast cells, histiocytes, and lymphocytes. Depending on the severity of the lesion, epidermal hyperplasia, erosions, ulcerations, and variable amounts of spongiosis and necrosis may be present.
The so-called “flame figures,” collagen fibers surrounded by degranulated eosinophils, are a commonly described finding but are not unique to this condition.