JVD 2019 #2 Use of Platelet-Rich Plasma and Platelet-Rich Fibrin in Dentistry & Oral Surgery: Introduction and Review of the Literature; Feigin, Shope Flashcards Preview

JVD 2019-2021 > JVD 2019 #2 Use of Platelet-Rich Plasma and Platelet-Rich Fibrin in Dentistry & Oral Surgery: Introduction and Review of the Literature; Feigin, Shope > Flashcards

Flashcards in JVD 2019 #2 Use of Platelet-Rich Plasma and Platelet-Rich Fibrin in Dentistry & Oral Surgery: Introduction and Review of the Literature; Feigin, Shope Deck (9)
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1
Q

Growth factors in platelets are responsible for….

A
Increased cell mitosis
Increased collagen synthesis
Blood vessel growth
Cellular recruitment
Other factors important for healing and regeneration of tissues
2
Q

What are platelet concentrates?

A

Concentrated suspensions of growth factors in platelets that act as locally applied bioactive surgical additives to induce wound healing

3
Q

What is platelet rich plasma?

A

Concentrate of PRP protein obtained from whole blood and centrifused to remove the RBCs

4
Q

What is platelet rich fibrin?

A

2nd-generation platelet-rich concentrate where autologous platelets and leukocytes are present in a complex fibrin matrix

5
Q

What occurs in the 1st centrifugation?

The second?

A

1- blood separates into 3 distinct strata (red corpuscules base, acellular plasma (PPP) and Max platelet concentration area)
2- platelet concentration at the bottom of the tube
cPRP: the platelet concentrate is suspended in an acellular plasma fraction

6
Q

What is the lifespan of inactivated platelets?

A

7-10 days

7
Q

How can platelet-rich fibrin be used?

A

Resorbable membrane for GTR as bioscaffold

8
Q

What are the known cytokines & growth factors in platelet-rich fibrin?

A

interleukin 1B (IL-B), IL-4, tumor necrosis factor alpha, PDGF A and B, TGF-B1, insulin-like growth factor 1, vascular endothelial growth factor (VEGF).
TGF-B1, PDGF-AB and VEGF released from PRF in highest amounts.
Has sustained release of growth factors for 1-4 weeks.

9
Q

Take-home message for Protocol for PRP preparation

A

8mL blood= 1ml PRP
1st spin= hard= separate the RBCs from plasma that contains platelets, WBCs and some clotting factors (buffy coat)
2nd spin= soft= separate platelet concentrate (PRP) from the platelet-poor plasma (PPP)
Use in 4 hours.
Release of growth factors begins within 10mins, almost 95% secreted in 1st hour

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