JVD 2020 #3 Biological Behavior of Canine Acanthomatous Ameloblastoma Assessed with CT and Histopathology: A Comparative Study; Goldschmidt

Question 1

Which tumors were associated with more invasive behavior as measured by computed tomography?

Answer 1

Predominantly intraosseous tumors

Question 2

How/in who does CAA present most commonly?

Answer 2

In the rostral mandible of adult large breed dogs, with Golden Retrievers overrepresented.

Question 3

Where is it hypothesized that CAA arises from?

Answer 3

Epithelial cell rests of Malassez, the dental lamina, the epithelial lining of an odontogenic cyst, or from basal epithelial cells of the oral mucosa (not current theory).

Question 4

Diagnostic imaging findings assoc w CAA were variable. What were the only consistent diagnostic findings?

Answer 4

presence of alveolar bone lysis (100%)
positive contrast enhancement (93%)
presence of cortical bone thinning (78%)

Question 5

What was intraosseous location significantly associated with?

Answer 5

Aggressive biologic behavior
tumor size
presence of bone expansion
periosteal bone proliferation
cortical bone thinning
severity of bone lysis
tooth displacement

Question 6

Of the intraosseous tumors, what % had severe or very severe bone lysis on diagnostic imaging?

Answer 6

10% severe & 90% very severe

Question 7

What percentage of tumors showed no mitotic figures in 10 high power fields?

Answer 7

31 of 44 (70.5%)

Question 8

Did this study find correlation between CT features and histological features of CAA?

Answer 8

No. CAA tends to have a highly uniform and predicatable histological pattern with tumors that aggressively invade bone not showing features of atypia that might be helpful in predicting biological behavior. = Histopath not a good predictor of biological behavior of CAA.