JVD 2020 #3 Biological Behavior of Canine Acanthomatous Ameloblastoma Assessed with CT and Histopathology: A Comparative Study; Goldschmidt Flashcards Preview

JVD 2019-2021 > JVD 2020 #3 Biological Behavior of Canine Acanthomatous Ameloblastoma Assessed with CT and Histopathology: A Comparative Study; Goldschmidt > Flashcards

Flashcards in JVD 2020 #3 Biological Behavior of Canine Acanthomatous Ameloblastoma Assessed with CT and Histopathology: A Comparative Study; Goldschmidt Deck (8)
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1
Q

Which tumors were associated with more invasive behavior as measured by computed tomography?

A

Predominantly intraosseous tumors

2
Q

How/in who does CAA present most commonly?

A

In the rostral mandible of adult large breed dogs, with Golden Retrievers overrepresented.

3
Q

Where is it hypothesized that CAA arises from?

A

Epithelial cell rests of Malassez, the dental lamina, the epithelial lining of an odontogenic cyst, or from basal epithelial cells of the oral mucosa (not current theory).

4
Q

Diagnostic imaging findings assoc w CAA were variable. What were the only consistent diagnostic findings?

A

presence of alveolar bone lysis (100%)
positive contrast enhancement (93%)
presence of cortical bone thinning (78%)

5
Q

What was intraosseous location significantly associated with?

A
Aggressive biologic behavior
tumor size
presence of bone expansion
periosteal bone proliferation
cortical bone thinning
severity of bone lysis
tooth displacement
6
Q

Of the intraosseous tumors, what % had severe or very severe bone lysis on diagnostic imaging?

A

10% severe & 90% very severe

7
Q

What percentage of tumors showed no mitotic figures in 10 high power fields?

A

31 of 44 (70.5%)

8
Q

Did this study find correlation between CT features and histological features of CAA?

A

No. CAA tends to have a highly uniform and predicatable histological pattern with tumors that aggressively invade bone not showing features of atypia that might be helpful in predicting biological behavior. = Histopath not a good predictor of biological behavior of CAA.

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