JVD 2019 #4 Humic Acid, a Polyphenolic Substance, Decreases Alveolar Bone Loss in Experimental Periodontitis in Rats, Calisir

Question 1

What are humic acids?

Answer 1

Humic acids are brown-black colored, polymeric, alkali-soluble organic acid fractions abundantly present in all soils (esp wetlands) and on the surfaces and bottoms of oceans and seas

Question 2

At the 15 day period, how did the alveolar bone loss compare between the control ligature-only group, control no-ligature and test groups?

Answer 2

Alveolar bone loss was significantly higher in the control ligature-only group compared to the no-ligature, 20mg/kg, and 150mg/kg groups.

Question 3

How did osteoclast number in the ligature only group compare to the other groups?

Answer 3

It was significantly higher compared to the no-ligature, L-20 and L-150 groups

Question 4

What serum and gingival homogenate interleukins were evaluated? Was there a significant difference in the groups?

Answer 4

Enzyme-linked immunosorbent assays for interleukin 1b (IL-1b) and IL-10 were measured. IL-1b was significantly higher in serum and gingival homogenate in the ligature only group compared to the test groups.
IL-10 was highest in the control no-ligature group.