JVD 2020 #4 The Use of Biphasic Calcium Phosphate Substitute (BCP) in Mandibular Defects in Dogs: Use of CBCT to Evaluate Bone Healing; Girard

Question 1

What material was used for repair of the mandibular bone defects in this case series?

Answer 1

Commercially available calcium phosphate ceramic bone void filler- Graftys BCP. This ceramic is a microporous and macroporous, 2-phase calcium phosphate ceramic made of 60% hydroxyapatite (HA) and 40% beta-tricalcium phosphate (B-TCP). This was mixed with autologous blood to make a sterile coagulum.

Question 2

How were quantitative bone density measurements taken?

Answer 2

Using CBCT multi-planar reconstructions. Grey-scale values were measured on the slice images and converted to density values ( Hounsfield Units HU)

Question 3

Did the HU density values of the implanted defects equal or exceed the HU of the contralateral mandible?

Answer 3

At 3 months, all defects had HU minimal values superior to the HU minimal values of the contralateral mandible. By 2 months, all defects had HU maximal values superior to that of the contralateral MN.

Question 4

Results indicated a gradual increase in density and homogeneity of the biomaterials with time. What does this associate with?

Answer 4

Mineral density filling the spaces between ceramic granules and between the peripheral bone defect margins and the implanted biomaterial.

Question 5

When was mineralization/new bone formation obvious in all CBCT performed in this series?

Answer 5

After 8 weeks