JVD 2020 #4 Biphasic Calcium Phosphate Microparticles Mixed with Autologous Blood: Application for the Reconstruction of a Large Mandibular Bone Defect in a Dog; Girard Flashcards Preview

JVD 2019-2021 > JVD 2020 #4 Biphasic Calcium Phosphate Microparticles Mixed with Autologous Blood: Application for the Reconstruction of a Large Mandibular Bone Defect in a Dog; Girard > Flashcards

Flashcards in JVD 2020 #4 Biphasic Calcium Phosphate Microparticles Mixed with Autologous Blood: Application for the Reconstruction of a Large Mandibular Bone Defect in a Dog; Girard Deck (8)
Loading flashcards...
1
Q

In prior combined surgical and regenerative method for reconstruction of critical size mandibular defects in dogs, what was used?

A

Collagen sponge containing granules of hydroxyapatite (HA) and beta-tricalcium phosphate infused with rhBMP. (Arzi 2015)

2
Q

What is BCP, biphasic calcium phosphate?

A

BCP is a combination of hydroxyapatite (HA) and beta-tricalcium phosphate (B-TCP) in the form of ceramic granules or combined with gel-polymers

3
Q

How does the combination of HA and B-TCP work?

A

HA is not resorbed and inert, thus provides a structural scaffold. B-TCP is rapidly resorbed, has bioactivity for osteoinduction and promotes tissue regeneration.

4
Q

What portion of blood was found to be responsible for induction of new bone formation in prior study of clotted whole blood with BCP microparticles?

A

The mononuclear cell fraction.

5
Q

What did the CaP biomaterial in BRB consist of?

A

calibrated 80-200 micrometer microporous microparticles of BCP, composed of 60% HA and 40% B-TCP in a ready-to-use kit

6
Q

Was any fixation used to adhere the gel form BRB cylinder or clotted composite to the bone ends or plate?

A

No. It was laid alongside the plate without any rigid fixation to the plate or bone. The surroundign soft tissue were sutured to provide soft tissue cover to the BCP/blood and implant plate.

7
Q

When was evidence of new bone bridging the interface between the implant material and the adjacent mandibular bone first observed?

A

At the 4 week-post surgery CBCT.

8
Q

What are the objectives of bone substitutes?

A

serve as a substrate for the migration, proliferation and differentiation of cells originating from surrounding tissues, followed by bone ingrowth.

Decks in JVD 2019-2021 Class (44):