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naplex > lab values and monitoring > Flashcards

lab values and monitoring Flashcards

1
Q

average lifespan of RBC?
average lifespan of plt

A

120days
7-10 days

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2
Q

BMP consists of

A

Electrolytes,
glucose,
renal function,
HCO3 or
bicarbs

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3
Q

Comprehensive metabolic panel

A

BMP + albumin, ALT, AST, Total bilirubin and protein

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4
Q

leukocytosis

A

increase in WBC

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5
Q

polycythemia

A

Increase in RBC

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6
Q

thrombocytosis

A

increase in PLT

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7
Q

myelosuppression

A

decrease in WBC RBC abd PLT

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8
Q

agranulocytosis

A

Decrease in WBCs that have granules neutrophilsm basophils and eosinophils

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9
Q

Calcium range and what meds alters it

A

8.5- 10.5
if albumin low check corrected CA
increases due to supplemetns vit D and THiazide diuretics
decreases due to long term heparin use, loop, bisphos, cincalcet, calcitonin, foscarnet and topiramate

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10
Q

MG

A

1.3-2.1
increases due to antacids and laxatives with renal impairment
decreases due to PPI, diuretics, ampb, foscarnet, echinocandins, diarrhea , alcohol

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11
Q

phosphate

A

2.3-4.7
increases in renal failure
decreases due to phosphate bincers, foscarnet, oral ca intake

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12
Q

Potassium

A

3.5-5
increases due to ACE, ARBS, ARNI, canagliflozin, cyclospoine, tacrolimus, K supplements, bactrim drospirenone containing oral contraceptives, NSAIDs
decreases due to beta 2 agonists, diuretics, insulin, steroids

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13
Q

NA

A

135-145
increases due to hypertonic saline
decrease due to carbamazepine, oxcarbazepine, SSRI, diuretics

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14
Q

Bicarbs

A

24-30 venous
increases due to loop, steroids
decreases due t topiramate, zonisamide, ASA overdose

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15
Q

BUN

A

7-20
increases due to renal impairment and dehydration

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16
Q

SCR

A

0.6-1.3
increases due to aminoglycosides, amph B, cisplatin, colistimethate, cyclosporine, loop. polymyxin, NSAIDS, dye, tacrolimus, vanc
decreases due to low muscle mass, amputation, hemodilution

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17
Q

anion gap

A

5-12
increases suggest acidosis

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18
Q

WBC

A

4-11x10^3
increases due to sytematic steroids
decreases due to clozapine, chemo, immunosupressants, vanc carbamazepine, cephalosporin

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19
Q

RBC

A

males- 4.5-5.5 X10^6
females 4.1-4.9 X10^6

increases with ESAs smoking
decreases due to chemo, anemias
scikle cell anemia

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20
Q

HGB

A

males- 13.5-18
females- 12-16

increase due to ESA
decrease due to anemia and bleeding
** coombs test and G6PD drug indduced anemias

21
Q

MCV

A

80-100
increase is due to B12 or folate deficiency
decrease is due to iron deficiency

22
Q

folic acid

A

5-25
decreases due to phenytoin, alcohol, prenatal, phenobarbital, mtx, bactrim

23
Q

vit B-12

A

> 200pg/ml
decrease due to PPI, metformin, colchicine, chloramphenicol

24
Q

Coombs test

A

needs to be negative if positive due to drugs:
penicillin, cephalosporin, methyldopa, methylene blue, quinidine, rasburicase, rifampin, sulfonamides

25
Q

G6PD

A

5-14
- decrease is due to dapsone, methtylene blue, nitrofurantoin, pegloticase, rasburicase, sulfonamaides

26
Q

anti factor XA activity

A

1-2 obtained 4 hours after LMWH
increase due to heparin, LMWH, fondapari

monitor in pregnancy obesity, low body weight, renal insufficiency

27
Q

PT/INR

A

PT 10-13 s and varies
INR <1.2 for not on warfarin
increase is due to warfarin or liver disease
false increase from daptomycin, oritavancin, telavancin

28
Q

PLT

A

150-450
<20k high bleeding risk
decrease due to heparin LMWH, fonda, linezolid, valporic acid Bone marrow chemo drugs

29
Q

albumin

A

3.5- 5
decreases due to cirhosis and malnutrition
drugs affected- warfarin, calcium, phenytoin

30
Q

BILI

A

0.1-1.2

31
Q

amylase and lipase

A

60-180 and 5-160
icnrease in pancreatitis- GLP DPP4 valporic and hypertriglycerdemia

32
Q

Creatine kinase or CPK

A

assess inflamation of muscle muscle damage due to- dapto, statin, tenofovirm raltegravir, dolutegravir

33
Q

troponin
BNP
NT pro BNP

A

0-0.1
<100
<61 Males
12-151 females
diagnosis of MI
BNP and NT BNP are for cardiac stress
higher values for HF

34
Q

thyroid
tsh

A

0.3-3
Increase of TSH hypothyroidism - amiodarone interferons, lithium, Tyrosine kinase inhibitors and carbamazepine
decrease of TSH hyperthyroidism - amiodarone interferons

35
Q

URIC acid

A

increase due to diuretics, niacin, low dose aspirin, cyclosporin, tacrolimus, chemotherapy

36
Q

g6pd defeciency and primaquine

A

increase destruction of rbc

37
Q

what drugs should not be taken for people with G6PD defeciency

A

methylene blue
dapsone
pegloticase

38
Q

CRP, RF, ESR, ANA

A

inflamation auto immune disorders
DILE

39
Q

What meds can cause DILE

A

hydralazine
isoniazid
methimazole
methyldopa
minocycline
procainamide
PTU
quinidine
termbinafine

40
Q

carbamazepine TI

A

4-12

41
Q

digoxin

A

0.8-2 afib
0.5-0.9 HF

42
Q

gentamycin

A

<2 trough
lithium

43
Q

lithium

A

0.6-1.2

44
Q

phenytoin

A

10-20
free = 1-2.5

45
Q

theophyllune

A

5-15

46
Q

valporic acid

A

50-100

47
Q

what long term use med can cause B12 def

A

PPI
metformin
colchicine
chloramphenicol

48
Q

aptt goal

A

1.5-2 times more than hospirtal goal

49
Q

steady state

A

5 doses

naplex (78 decks)

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