Lecture 44: T Cells Flashcards Preview

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Flashcards in Lecture 44: T Cells Deck (17):
1

Within the ER, peptides along with other things are loaded on to the MHC class __ molecule.

- I (one)

2

How are MHC-II molecules loaded with peptides?

- Phagocytosis
- Phagolysosome formed
- Class II loads peptide on (in phagolysosome)
- Specificity

3

DC can present viral antigens via MHC-__? It's a rule breaker in the regard that a virus is able to take both class I and class II pathways.

- II

4

Dendritic cells travelling through lymphatic vessels it will eventually arrive in a lymph node, and meet __ cells. Of all cells, DCs make up _%.

- T
- 1

5

DCs nestle in the __ cell areas and if you zoom in you can see that they're right amongst them.

- T

6

CD4 T Cell is able to provide help usually in the form of _______.

- Cytokines

7

T Cells are _______ that arise in the ___ ______ and fully develop in the _____. T Cells express T Cell Receptor with co-receptors (either ___ or CD8)

- Lymphocytes
- Bone
- Thymus (university)
- CD4

8

The Thymus is used to weed out...

- Weak / Useless / Dangerous T Cells
- Screens all T Cells
- Only useful T Cells are allowed to emerge

9

Gene rearrangement occurs so that T Cells express unique ______. There's a large number of them, big library, don't know which may save our lives but know that some will. Different T Cells operate during different infections.

- Receptors

10

CD4 = ? CD8 = ?

- Recognises MHC-II peptide
- MHC-I

11

CD4 T Helper Cell:

- Helps CD8-T become cytotoxic
- Cytokine (eg IL-1) production

12

CD8 T Cell recognises...

- MHC-I peptide
- Develops into Cytotoxic T Cell

13

What do Cytotoxic Cells do?

- Releases enzymes that virally infected cells receive and "kill themselves"

14

HIV attacks what receptors?

- CD4

15

Memory T Cells are much quicker than ____ T Cells because they have ____ activation, and are there in _____ numbers.

- Naive
- Lower
- Greater

16

Natural Killer Cells DO NOT have a _____ receptor. Their job is to....

- T Cell
- Kill tumour cells or virus infected cells that have low or absent MHC-I
- No mercy shown (forgetting your passport / wallet)

17

REVISE

what happens during bacterial infections + virus infections