Lecture 46: Humoral Immune System Flashcards Preview

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Flashcards in Lecture 46: Humoral Immune System Deck (13):
1

Describe the structure of a B-Cell Receptor

- 2 Heavy Chains
- 2 Light Chains
- Disulfide bridge between two heavy chains
- Antigen binding site at tips of 'Y'
- Variable + Constant regions

2

Different _____ for different B-Cells. Antigens don't need to be ______ / a peptide to be recognised.

- Antigens
- Processed (in a membrane)

3

B Cells (and T _____) are unique. Most B cells ( or _ Cells) express a different receptor. IgM and IgD are the predominant classes of ______ expressed on ___ B Cells. BCR IgM is present as a monomer, secreted IgM is a pentameter.

- Cells
- T
- Antibodies
- Naive

4

During a parasite infection, you'd want a lot of ___ around.

- IgE

5

Constant regions on the antibody are able to be _____.

- Switched

6

B Cells undergoing class switching maintaining their ____ _____.

- Antigen Specificity

7

Class / Isotype switching:

- IgM / IgD --> IgG --> IgA --> IgE
- Has to go in this direction
- Can't go backwards because you're looping out genes that have been tossed out and degraded
- Some steps can be skipped

8

Clonal Selection:

- Selective expansion of unique B Cell Clones that interact with antigen
- Selective specificity
- Antigen specific B Cells then process and display (using MHC-II) to helper T Cells
- Helper T cells squirt out cytokines on to B Cells

9

B Cells that recognise _____ during an immune response are stimulated to undergo ___ ______.

- Antigen
- Cell Division

10

What is the difference between memory B Cells and Clone Plasma Cells?

- Antibody used as receptor on memory B Cells

11

Memory responses:

- Stimulation of B cells by antigen + T cell and lymphatic tissue
- Express antibody as BCR, but do not secrete antibody
- Respond rapidly to antigen encounter and become plasma cells

12

Primary Immune Responses:

- Takes about 7-14 days before sufficient antibody is produced to eliminate pathogen
- Relatively low amount of antibody produced - mainly IgM (pentameric form)
- Very good at activating complement

13

Secondary Immune Responses:

- Basis of the success of vaccination
- Relies on memory B cells
- Fast: 2-3 days, sufficient antibody is produced to eliminate pathogen - mainly IgG

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