List #7 Flashcards
myelin
-lipid material that forms a sheath like covering around some axons
axonal transport
- movement occurs in both directions between the cell body and the ends of the axon.
- enzymes required for neurotransmitter synthesis are produced in the cell body and transported to the axon terminals.
membrane potential
- The potential difference across the cell membrane(measured in millivolts)
resting membrane potential
- one that is not sending impulses or responding to other neurons(-70 millivolts)
action potential
- a rapid change in the membrane potential, first in a positive direction, then in a negative direction, returning to the resting potential
- all or nothing
- regenerative
depolarization
- if the membrane becomes more positive than the resting potential
- can be caused by Sodium entering
- means the threshold is lowered for an action potential
hyperpolarization
- if the membrane potential becomes more negative than the resting potential
- the threshold is raised
refractory period
- During the absolute refractory period which lasts about 1/1,000 of a second, the axon’s voltage-gated sodium channels are temporarily not responsive at all, and the axon cannot be stimulated.
- Then the relative refractory period follows, as the membrane reestablishes its resting potential.
saltatory conduction
- Action potentials appear to jump form node to node
- conduction on myelinated axons is many times faster than conduction on unmyelinated axons
synaptic potentials
- enable one neuron the affect another
- EPSP/IPSP
- graded
- non-regenerative
EPSP
- A neuro transmitter binds to a post-synaptic receptor and opens sodium ion channels, the ions diffuse inward, depolarizing the membrane possibly triggering an action potential.
- lasts for about 15 milliseconds
- Depolarizing
- Glumate
IPSP
- A different neurotransmitter binds other receptors and increases membrane permeability to potassium ions, these ions diffuse outward hyperpolarizing the membrane
- Hyperpolarizing
- GABA
monoamines
- modified amino acids
neuropeptides
- These peptides act as neurotransmitters or a neuromodulators, which are substances that alter a neurons response to a neurotransmitter or block the release of a neurotransmitter.
- enkephalins and endorphins
enkephalins
-Generally inhibitory; reduce pain by inhibiting substance P release (CNS)
glutamic acid (glutamate)
-Generally excitatory (CNS)
monoamine oxidase
- Inactivates the monoamine neurotransmitters epinephrine and norepinephrine after reuptake
- It is found in the mitochondria in the synaptic knob
serotonin
-Primarily inhibitory; leads to sleepiness; action is blocked by LSD, enhanced by selective serotonin reuptake inhibitor antidepressant drugs (CNS)
tryptophan
- Neurotransmitter affected: Serotonin
- Mechanism of Action: Stimulates neurotransmitter synthesis
- Effect: sleepiness
dopamine
- Creates a sense of well-being; deficiency in some brain areas associated with Parkinson disease (CNS)
GABA
- Generally inhibitory (CNS)
endorphins
-Any group of neuropeptides synthesized in the pituitary gland and hypothalamus that suppress pain
meninges
- located between the bone and the soft tissues of the nervous system
- They have three layers the dura mater, arachnoid mater, and the pia mater
spinal nerves
-Nerves that arise from the spinal cord