M7 Infections if the Upper Respiratory Tract Flashcards Preview

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Flashcards in M7 Infections if the Upper Respiratory Tract Deck (84):
1

what does pyogenic mean

causes an elevation in temp - heat

2

what is a pyogenic bac

streptococcus pyogenes

3

what are the evolutionary groupings of streptococcus

angiosus
Oralis
Mutans
Salivarius
Pyogenic
Bovis

4

what are some sp of S. orals

s snaguinis
s cristasus
s gordonii
s mites
s oralis
s pneumoniae

5

what is a pyrogen

agent that causes raise in body tissue

6

what are GAS

Group A Streptococcus

7

what types of bac are GAS

streptococcus pyrogens
assc with diseases

8

what are iGAS

invasive GAS

9

what kind of disease can GAS cause

systemic
major pathogen in skin conditions

10

what is important to not about a s. pyrogens capsule

hyuloronic acid interfere with complement and Ab

11

what is important to know of bodies reservoir function

micro biome
commensals
priming immune system

12

where is a common site fro s progenies

oropharynx

13

what si percentage of s pyogenes in adult vs children nd why

10% adult
20% children
immune system developing and more susceptible to exposure

14

where is most comply adhesion occur

oropharynx
nasopharynx

15

what allows adhesion at sites

non ciliate cells covered in mucus
range of adhesins

16

what acts as defence to the upper resp tract

mechanical washing
cough reponse
shedding
mucociliary clearance
microbiota/flor

17

what are some infectious organisms in the resp treat

bacteria
viruses
fungi

18

what is viral pharyngitis

normal cold virus
only need symptomatic therapy 70%

19

what is a bacterial ppharyngiits

strep throat
GAS 15%
- beta haemolytic S.pyogenes

20

what complications can occur due to bacterial pharyngitis

acute rheumatic fever

21

what are some common batter seen in pharyngitis

fusoacterum necrophorum
mycoplasma pneumonia
haemophilia influenza

22

what can pharngiti lead to

tonsilitis

23

what represents bacterial pharyngitis

swollen uvula
whitish spots
red swollen tonsils
redness gray furry tongue

24

what is viral pharyngitis shown by

red swollen tonsils
throat redness

25

what are some symptoms of viral pharyngtiits

absence of fever
conjuntivitis
coryza
cough

26

what is coryza

inflammation of nasal mucous membranes

27

what are the symptoms of strep throat

sudden onset
sore throat
fever
patchy exudates
tiny red spots on hard palate
tender cervical nodes

28

what are some other complications that can further from strep throat

tonsillitis
ottis media
sinusitis

29

if there is bad breath asscw with a sore throat what can this mean

bacterial pharngitits recgo necrotising damage to tissue as being broken down
proteins being broken = odour

30

What can happen from a more aggressive strain of S. pyogenes

bacteriophage presses haemolytic toxin cause damage to RBC leading to scraeltine appearance

31

what does a super antigen do

overstimulates system

32

what is scarlet fever

severe form of strep throat with assc rash

33

what causes the effects of scalet fever

pyrogenic/erytorogenic exotoxins

34

what does a scared fever show

typical rash 2 days after illness
contagious
flushed red face
coated tongue
swollen tonsils

35

the does GAS come about

periodic epidemics
possible increasing

36

when are GAS skin diseases common

in young children
poor hygiene sharing towels

37

what is ana example of a GAS skin disease

impetigo

38

what is impetigo

usually face
high contagious
contact with discharge on face
infections immediately beneath surface

39

what does impetigo show as

sores on stratum core which then goes beneath skin layer invasive GAS

40

what do GAS skin diseases usually do after colonising skin

disease moves deeper tissue or involves lymphatic system

41

what does range of spreading subcutaneous skin infections caused by

iGAS
invasive GAS

42

what is Cellulitis

deeper skin infections in the dermis
develop in lesion

43

what is erysipelas

localised
fever, rotors, nausea

44

what is necrotising fasciitis

rapid destroy CT
IGAS penetrate mucous memes and develop in deep lesion

45

what is mortality rate of necrotising fasciitis

20%

46

what is acute streptococcal gingivitis

infected gigivae
red swollen
oedematous
follow sore throat

47

what is TSLS

toxi shock like syndrome

48

what si the morality of TSLS

30-60%

49

what causes TSLS

pyrogenic exotoxins
complications of invasive infections
hypooension to organ failure

50

what dosuperantigens do

activate 1/5 T cells
assc with TSST-1
massive please cytokines and inappropriate immune response

51

what does a asuperantigen bind to

directly MHCII complex
outside conventional binding groove

52

what is rheumatic fever

autoimmune disease

53

what are the symptoms of rheumatic fever

sudden onset
early --> fever, joint pain, nose bleeds, vomit

late --> polyarthritis, inflam of joints and heart
pancarditis

54

what is pancrditis

peri, tyco and endocardium affected

55

when is rheumatic fever most likely to occur

young children 5-15
1-4 weeks after are throat
inadequate recoervy from GAS

56

what is the autoimmune disease PSGN

Post streptococcal Glomerulonephrotis

57

what happens in PSGN

inflam of glomeruli due to depo of Ag-Abs

58

what kind of hypersensitivity is PSGN

type 3

59

what are the key elements involved in adhesion

lipoteichonic aid
M protein
F protein
Hyaluronic acid

60

what does lipoteichonic acid act as

LTA
fibronectin - FA binding site

61

what does M protein do

fibronectin
and specific binding site

62

what is f protein

fibronecting binding protein
fibronetin

63

what does hyaluronic acid do

capsule
CD44 +ve keratincytes

64

what is used to identify class Streptococcis

haemolysis

65

what is an example of biactrin sensitive

GAS

66

when something is beta haemolytic what does it do on blood agar

clear zones around colony

67

what is the lance field system

group a terminology
serotyping cell wall carb

68

what is group A subdivide by

M protein antigens
M1 & M3 - major serotype
M3 & M18 - major invasive

69

what is M protein involved in

adhesion
evading immune system
antiphagocytic
prevent 3b bind
opsonisation via alternate path

70

what are other ways of evasion of host defences

SpyCEP - protease cleaves IgG
C5a peptidase - cleave C5a

71

what is Sic and what does it do

strep inhibitor of complement
binds C5b & C7
evasion of host defences

72

what do pyrogenic exotoxins do as super antigens

evasion of host def
SpeA and SpeC - scarlet fever
SPeG..... assc with rheumatic fever

73

what causes tissue destruction nd spread

numerous virulence factors

74

what re some virulence factors able to increase tissue destruction nd spread

haemolysins
DNase A,B, C, D
Streptokinase

75

what do virulence factors all do

liquefaction of Pus
destroy tissue
dissolution of clot

76

what is key to iGAS

target immune cells for cel destruction

77

what are streptolysins (SLS)

pore firing cytolysin
toxic to PMN, organelles, platelets

78

what is metastasis

tissue penetration

79

what ar the factors involved in metastasis

m protein
fibronetin binding protein

80

what si the function of m protein in metastasis

stimulates internalisation

81

what is fibroncetin binding protein function in metastasis

hide from macrophages
presist in presence of Ab

82

whats the most affective Ab treat

penicillin V 10 day course

83

what is amoxicillin

narrow spectrum acceptable to children

84

when is erythromycin used

patients sensitive to penicillin