Membrane proteins

Question 1

Proteins permanently attached to a membrane

Answer 1

Integral membrane proteins

Question 2

Number of times a polypeptide chain spans the membrane

Answer 2

Topology

Question 3

What determine the number of transmembrane alpha helices

Answer 3

Number of topogenic sequences

Question 4

What determines whether the N or C terminus lies in the the cytosol

Answer 4

Orientation

Question 5

Terminal end with the greater number of _______ amino acids will be inserted in the cytoplasm

Answer 5

Positive

Question 6

If the greater number of amino acids comes before the insertion segment the __ terminal will be in the cytoplasm

Answer 6

N

Question 7

How are ER integral membrane proteins classified

Answer 7

Single vs multi pass and their orientation

Question 8

Single pass insertion proteins with a cleaved ER signal sequence are anchored to the membrane with

Answer 8

Stop transfer anchor sequence

Question 9

Integration of single pass transmembrane proteins with an internal signal sequence are anchored with

Answer 9

Signal anchor sequence

Question 10

Polypeptide chain passes back and forth repeatedly across the lipid bilayer

Answer 10

Multi pass membrane proteins

Question 11

True or false: Hairpins are present in multi pass membrane proteins

Answer 11

True

Question 12

Internal sequence acts as both ER signal sequence and anchor sequence

Answer 12

Single pass

Question 13

Integral membrane proteins insert into the plasma membrane using

Answer 13

Vesicles

Question 14

True or false: signal peptidase cleaves the ER signal sequence of single pass proteins

Answer 14

False (only in multi pass)