The importance of cell matrix adhesion Flashcards
(23 cards)
Direct links
Cell-cell interactions
Indirect links
Cells held within the
extracellular matrix (ECM)
Cells in tissues are embedded within a network of molecules called the ____________
Extracellular matrix (ECM)
Thin fibrous sheet of specialised ECM that lies
underneath sheets of epithelial cells and separates
cells from connective tissue
Basal lamina
Components of the basal lamina
Collagen IV and laminin, crosslinked to
other glycoproteins
What is the basal lamina involved in
Cell attachment, growth and migration
What does the basal lamina do in the kidney glomerulus
Determines which molecules pass from blood into urine
What are the components of the ECM
Fibres (collagen, elastic, reticular), adhesive glycoproteins (fibronectin, laminin), ground substance
What is the role of fibroblasts
Produce and secrete ECM molecules
What is the main function of fibroblasts
Maintain structural integrity of connective tissue by continuously
remodeling the ECM
When a tissue is injured, _________ proliferate, migrate into wound, and produce large amounts of collagenous matrix, which helps to isolate and repair the damaged tissue
fibroblasts
What is the most abundant protein in animals
Collagen (25%)
What is the structure of collagen fibres
3 collagen strands wrapped around each other to form a super-
helical rope-like structure
What are the properties of collagen fibres
Support tissue and provide very high tensile strength
What do integrins do
Attach cells to the ECM by binding to fibronectin, laminin and
collagens
What connects ECM to actin cytoskeleton
Integrins (cell-matrix adhesion)
Large multi- protein complexes that link the
cell actin cytoskeleton (via integrins) to the ECM
Focal adhesions
What allows cells to sense and respond to changes in chemical composition and physical properties (e.g. stretching, mechanical pressure) of the ECM
Cell-matrix adhesions
________________ reach out to nearby vessels and are used as
highways by cancer cells to migrate, promoting invasion and
metastasis
Collagen fibres
What must epithelial cells do in order to respond to
growth factors and divide
Attach to the ECM
Cell detachment mediated cell death
Anoikis
What type of cells does anoikis eliminate
Misplaced cells
Cancer cells overcome anoikis and become __________
anchorage independent
