Ubiquitin proteosome system

Question 1

Protein tag that marks proteins for degradation

Answer 1

Ubiquitin

Question 2

The number of ubiquitin molecules added affects

Answer 2

The fate of the target protein

Question 3

Chains of ubiquitin mark proteins for destruction by the

Answer 3

Proteasome

Question 4

Ubiquitin chain that marks the protein for proteasomal degradation

Answer 4

Lys48

Question 5

Ubiquitin is prepared for conjugation by

Answer 5

Ubiquitin activating enzyme (E1)

Question 6

E1 binds to the protein machine _______ complex

Answer 6

E2-E3

Question 7

Activated E1 is transferred to ____

Answer 7

E2

Question 8

Misfolded proteins are recognised by ________

Answer 8

Degradation signals

Question 9

____ recognises degradation signals and binds to protein

Answer 9

E3

Question 10

____ adds ubiquitin chain to Lysine found on a target protein

Answer 10

E2

Question 11

Polyubiquitin chain is recognised by the

Answer 11

Proteasome

Question 12

Active sites of the proteasome face the ________ to prevent digesting everything inside a cell

Answer 12

Inner chamber

Question 13

What enzymes are used to pass protein through proteasome

Answer 13

Unfoldases

Question 14

Role of E1

Answer 14

Adds ubiquitin

Question 15

Role of E2

Answer 15

Adds polyubiquitin chain

Question 16

Role of E3

Answer 16

Binds to protein to be degraded

Question 17

Change at one binding site causes a change at a distant binding site

Answer 17

Allosteric change

Question 18

Ubiquitin proteosome system inhibitors can be used to treat

Answer 18

Cancer