MicroBioFinal - HemmorhagicFever Flashcards Preview

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Flashcards in MicroBioFinal - HemmorhagicFever Deck (8)
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1

disease agent

Ebola Virus
- filamentus virus: enveloped (protein coat looks like pretzel), negative sense RNA, RNA transcriptase, release by budding
- replicate in macrophages, endothelial cells (on every organ), epithelial cells (skin)

2

disease agent (viral replication)

1. attatchment
2. penetration - everything gets in but envelope
3. uncoating
4. biosyntheses - RNA polymerase copies (-) sense RNA into (+) sense RNA which is used by the ribosomes of the host cell to produce more virus parts
5. assembly and maturation
6. release by budding

3

transmission

* stable at room temperature for days
- contact with respiratory secretions: indirect fomite (possibly contact aersol)
- can get from saliva, sweat, tears: direct contact
* has to get in to your nose, mouth, eyes

4

symptoms

- 3 day incubation
- 4 day prodromal symptoms: headache, fever, malaise, myalgia
- 3-4 day disease symptoms - liquify organs:then blooody diarrhea, bleed from eyes& nose, skin fills with bloody boils
- around day 4 DEATH OCCURS = 90% death rate

5

treatment

- none for D.A
- therapies - Aggressive Rehydration

6

detection

can do RNA fingerprint

7

prevention

* avoid transmission: wear BSI, disinfect, wash hands, quarantine
- avoid host: current guess is bats b/c they carry large amounts of RNA viruses (high mutation rate)

8

epidemiology

- shows up destroys villages not seen for years
* avoid bats