MicroBioFinal - HemmorhagicFever

Question 1

disease agent

Answer 1

Ebola Virus

• filamentus virus: enveloped (protein coat looks like pretzel), negative sense RNA, RNA transcriptase, release by budding
• replicate in macrophages, endothelial cells (on every organ), epithelial cells (skin)

Question 2

disease agent (viral replication)

Answer 2

1. attatchment
2. penetration - everything gets in but envelope
3. uncoating
4. biosyntheses - RNA polymerase copies (-) sense RNA into (+) sense RNA which is used by the ribosomes of the host cell to produce more virus parts
5. assembly and maturation
6. release by budding

Question 3

transmission

Answer 3

• stable at room temperature for days
• contact with respiratory secretions: indirect fomite (possibly contact aersol)
• can get from saliva, sweat, tears: direct contact
• has to get in to your nose, mouth, eyes

Question 4

symptoms

Answer 4

• 3 day incubation
• 4 day prodromal symptoms: headache, fever, malaise, myalgia
• 3-4 day disease symptoms - liquify organs:then blooody diarrhea, bleed from eyes& nose, skin fills with bloody boils
• around day 4 DEATH OCCURS = 90% death rate

Question 5

treatment

Answer 5

• none for D.A

- therapies - Aggressive Rehydration

Question 6

detection

Answer 6

can do RNA fingerprint

Question 7

prevention

Answer 7

• avoid transmission: wear BSI, disinfect, wash hands, quarantine
• avoid host: current guess is bats b/c they carry large amounts of RNA viruses (high mutation rate)

Question 8

epidemiology

Answer 8

• shows up destroys villages not seen for years

* avoid bats