MicroBioFinal - Influenza(Flu) Flashcards Preview

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Flashcards in MicroBioFinal - Influenza(Flu) Deck (9)
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1

disease agent

Influenza Virus: many types; H1NI (Swine Flu) is the one we're focusing on now
- enveloped virus, 8 negative single stranded RNA
- 8 capsids with a piece of RNA and enzyme transcriptase in each
- has nametages - lollipops (N-spikes: neuraminidase) and cone shaped (H-spikes: hemagglutination)

2

disease agent (H1N1 Swine Flu Replication)

1. attachment - likes epithelial cells of respiratory tract
2. penetration
3. uncoating
4. biosynthesis - turn -RNA into +RNA (+RNA makes proteins and some make -RNA)
5. assembly and maturation
6. relsease by budding - *high error rate = high mutation rate (1/10,000)

3

what is a Reassortment?

Pandemic Flue happens b/c more than one virus invades one cell @ a time and this causes a different virus to be formed
***H1N1 is a quadruple reassortment, 2 swine versions, 1 human version, 1 avian (bird) version

4

transmission

- direct contact by respiratory secretions, contact aersol, indirect fomite

*Upper respiratory tract disease (URT) and sometimes lower respiratory tract disease (LRT)

5

symtoms

1. incubation: 1-4days (1 is most common)
2. disease - 3-5days; acute onset of fever, headache, chills, malaise, myalgia, cough/yellow sputum, sore throat
*contagious 1 day prior to symptoms - 7 days after onset
- can have lasting myalgia and malaise for weeks
immune response = normal

6

detection

- most dont go to hospital
- Neutralization Assay - doesnt tell you which type; to confirm you have flu; must confirm with RT-PCR and DNA fingerprint (rarely done b/c of bad science)

7

treatment

NO CURE.
- ex: TamiFlu - Neuraminidase inhibitors (N. spikes)
* must treat within 48hrs inital onset

8

prevention

- proper hygiene & avoid transmission: wash hands, disinfect
- vaccine availbale each year (70-90% effective); take 5 of the nametags of the one that might be most prevalent and then mature it in eggs)

9

epidemiology

US
- dec 16%
- jan 24%
- feb 40%
- march 12%
- april 4%
- may 4%

* swine flue - 0.02%: same as regular flu