Module 11: Transplant Immunology Obj. 4 Flashcards Preview

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Flashcards in Module 11: Transplant Immunology Obj. 4 Deck (8)
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1

Clinical relevance of HLA system (6)

Natural Function
Anthropology
Paternity testing
Platelet transfusions
HLA and disease susceptibility
Organ, bone marrow, HPC and stem cell transplant

2

Natural function

participation in the recognition of immunogens and regulation of immune response

3

PLT transfusions

HLA class I Ag carried in high concentrations on PLTs
Multiple transfusions = develop Ab to HLA Ag on the transfused leukocytes or PLTs

4

2 problems that HLA Ab may lead to (from recurrent transfusions)

Pt becomes refractory to PLT transfusions because the pats are sensitizes (coated with Ab) and removed rapidly

Non-hemolytic transfusion reaction may occur in response to HLA Ag

5

HLA and disease susceptibility

HLA is a poor presenter of viral/bacterial Ag
Provide poor binding site

In MS and ankylosing spondylitis with high HLA-B7 and HLA-B27, cell mediated immunity is depressed

6

Typing done for kidney transplant

ABO and HLA (A, B, DR)
Recipient checked for existing HLA Ab

7

Typing done for heart and liver transplant

ABO
Physical size compatibility
Seriousness of disease
Finally, HLA match and HLA Ab screen on recipient

8

Typing done for Bone marrow/HPC transplant

HLA match (A, B, DR, DQ)
ABO NOT REQUIRED