Module 8: Secondary Immune Deficiencies Flashcards Preview

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Flashcards in Module 8: Secondary Immune Deficiencies Deck (10)
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1

Secondary immune deficiencies occur sometime

after birth

2

Conditions that may lead to secondary immune deficiency

Hematologic/Lymphoproliferative disorders

Systemic Process/Metabolic diseases (Malnutrition)

Viral infections

Surgical procedures/ trauma

Immunosuppressives

3

Immune response to HIV

Massive expansion of CD8 lymphs
Ab to HIV proteins appear
CD4 T lymph numbers drop (causing risk of general infection)

4

Immune system evasion by HIV (3 ways)

HIV constantly mutates (evading detection by Ab)
HIV may internalize MHC I antigen on cells they infect
HIV may inhibit cell mediated immunity

5

3 things done before hematopoietic stem cell transplant

Recipient and donor are HLA matched
Recipient's immune may be suppressed
Graft may be processed (reduction of unwanted cells)

6

What does an HPC transplant do

provides recipient with stem cells which will repopulate the recipients bone marrow

7

3 major complications of HPC transplant

Rejection (host attacks graft)

Graft vs host disease (graft attacks host)

Immunodeficiency in the recipient (due to immune suppression, recipients ability to generate a complete new lymphocyte population, lag time during transplant)

8

Immune senescence

process of growing old and declining immune response
-increased risk of infection
-autoimmune disease

9

When does thymus reach is max size

puberty

10

increased age leads to decreases in

thymus size
t cell proliferation
primary antibody response
cytokine production
phagocytic activity