Module 11: Transplant Immunology Obj. 1 SA Flashcards Preview

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Flashcards in Module 11: Transplant Immunology Obj. 1 SA Deck (9)
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1

Human leukocyte antigens are called histocompatibility antigens because

they are involved in graft rejection or ocompatibility

2

What are HLA encoded by

MHC genes
3 classes of MHC genes

3

Class I MHC genes

Class I MHC Ag
HLA - A, B, C, (E, F, G)
(cell membrane proteins)

4

Class II MHC genes

Class II MHC Ag
HLA - D: DR, DQ, DO, DM, DP
(cell membrane proteins)

5

Class III MHC genes

Class III MHC Ag
HLA - C2, C4, and BF (factor)
(secreted complement components)

6

Tissue typing usually involves identifying

MHC class I molecules HLA-A and HLA-B
MHC class II molecule HLA-DR

7

HLA antigens serve 2 purposes

Bind to and present foreign antigenic peptides to T cells, thereby initiating the immune response

Distinguish the membrane antigens on a transplanted donor organ/tissue from those of the recipient (initiating tissue rejection)

8

Haplotype

set of alleles (one from each group from each parent)

9

phenotype

a listing of all the alleles identified in an individual

ex. HLA- A5, A2; B8, B51; DR17, DR11.