Module 11: Transplant Immunology Obj. 6, 7 SA Flashcards Preview

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Flashcards in Module 11: Transplant Immunology Obj. 6, 7 SA Deck (7)
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1

3 classifications of graft rejection

hyper acute
acute
chronic

2

Hyperacute rejection

occurs immediately due to pre-existing Ab to the ABO Ag or MHC Class I Ag
Preformed Ab bind complement and lead to vascular damage

3

Acute rejection

occurs within first few days-weeks
Due to activation of T cells in recipient to donor Ag
May be prevented by use of immunosuppressive drugs

4

Chronic rejection

Occurs over long period of time (even years)
Gradual loss of graft tissue structure and function
Both cellular and humoral

5

Graft vs. Host disease

occurs in severely immunocompromised patients
T lymphs from donor tissue recognize Ag of host as foreign and mount an immune response against them

6

Graft vs. host disease can also occur in immunocompetent recipients of blood from a biologically related donor because

the repent will not recognize the donor as foreign, but the donor will see the recipient as foreign

7

Requirement for all direct donation blood products

Blood is irradiated to prevent graft vs. host disease (kills WBC)