Module 9: Autoimmune Disease Flashcards Preview

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Flashcards in Module 9: Autoimmune Disease Deck (11)
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1

Autoimmunity

immune response that the body produces against its own cells or tissues

2

2 main factors of developing autoimmunity

inheritance of susceptible genes
Environmental trigger

3

other factors contributing to autoimmunity

Anatomic alterations
Hormonal influences
Defect in T regulatory cells

4

Central tolerance

immunological tolerance that develops int he thymus and bone marrow

As B and T cells mature, they are exposed to self antigens
Cells with high affinity to self antigens are removed

5

Negative selection

removal of B and T cells that have a high affinity to self antigens

6

Receptor editing

B cells may change specificity of their Ig receptor so that they will no longer recognize self antigens

7

T cells that recognize self antigens may develop into

T regulatory cells which enter peripheral tissues

8

Peripheral Tolerance

If B and T cells escape central tolerance, they are removed by:
Anergy
Deletion (cell death)
Suppression

9

Anergy

Inactivity or lymphs even though antigen is present
This is done by:
-Signaling by the TCR complex is blocked
-Inhibitory signals are relieved resulting in anergic T cells

10

Deletion (cell death)

occurs when T lymphs are activated by self antigen
This is done by:
-apoptosis
-death receptors are engaged (leads to apoptosis)

11

Suppression

occurs when self reactive T lymph develops into reg cells (function to suppress other self-reactive lymphocytes)

Reg T cells:
-produce inhibitory cytokines
-Block B7 on APC
-Bind IL2