Module 9: Organ Specific Autoimmune Diseases Flashcards Preview

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Flashcards in Module 9: Organ Specific Autoimmune Diseases Deck (10)
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Hashimoto's thyroiditis

loss of thyroid function

Ab to thyroid antigens (humoral) including anti thyroglobulin antibody and Thyroid peroxidase antibody
Lymphocytic infiltration of thyroid gland

Presence of antithyroid Ab
Increased TSH

Women 30-60y.


Graves disease

Thyroid gland is over stimulated

Autoantibody mimics TSH

Increased levels of thyroid hormones
Decreased TSH


Autoimmune Chronic Active Hepatitis (AI-CAH)

Loss of tolerance against liver tissue

Infiltration of lymphs cause histological changes to structure and function of liver

Decreased Tregs cell function
Increase Ig levels
Increased ANA
Increased SMA (Smooth muscle Ab)


Primary Bilary Cirrhosis

Loss of tolerance against liver tissue

Cirrhosis of small bile ducts in liver leads to hepatic failure

Increased anti-mitochondrial Ab (94% pts)
Decreased Treg cell function


Myasthenia Gravis

Auto-Ab against Acetylcholine receptor prevents muscle from contracting


Multiple Sclerosis

infiltration of lymphs into lesions


Diabetes Mellitus

Beta islet cells of the Pancreas are severely decreased or fibroses

Auto-Ab initiates CD4/CD8 response that results in beta cell destruction

Islet cells Ab, Insulin Ab, GAD Ab present

Environmental insult (virus), genetic susceptibility, autoimmunity


Goodpastures Syndrome

Circulating Ab to collagen of alveolar and glomerular basement membranes which bind complement

Increased antiglomerular basement membrane Ab


Celiac disease

CD4 T cells are activated, release inflammatory cytokines
Increased IL-15 expression leads to other cellular activity

Anti-TTG Ab present



Chronic hardening and contraction of the skin

T and B cells induce abnormalities of fibroblast collagen production and vascular injury
Genetic and environmental factors are thought to contribute