MS Flashcards

1
Q

what part of the spine does ms effect

A

white mater

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2
Q

how does ms effect the spie

A

caues demylation and inflatom of the spine

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3
Q

course of ms disesease

A

it is remitiing disease, ie gets worse then better gradually

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4
Q

how preveanlt is ms

A

1 in 300 people

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5
Q

where is ms found more

A

it is more prevalent the further north you go

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6
Q

which gender does ms mainly effect

A

females

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7
Q

what viurs may ms be associated with

A

epstein barr viurs

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8
Q

common problems in ms relapse

A

optic neurtisi - inflamtion of optic nerve
sensory smpons
brian stem - diplopia (double vision), vertiog
spinal cord – bilatler motor symptons#
bladder inovmvetn

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9
Q

signs of optic enuritsi

A

vision loss
pain in movnig eye
colour vision impaired
resolves within weeks or months
swelling of the optic disc
cuaes pupill defect

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10
Q

what is relative affernt pupillary defect

A

where wehn a tourch is shined on a pupil it will cause it not to constrict due to damage to optic nerve, when shine on other pupil both pupils will constic

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11
Q

which part of the brain is internuclear ophthalmoplegia associated with

A

pons

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12
Q

what is sigs of internuclear ophthalmoplegia

A

diffucily moving both eyes horizonally at the same time
one eye will have nystagmus towards the lateral aspect and the other eye will not move

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13
Q

effect of spinal cord lesion in ms

A

cuase band of hyperaesthis or numbes in the area
can cause bladder or bowel problems

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14
Q

what type of cell is responsibel for demylination

A

activated t cells crossing the bbb

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15
Q

what is required for an ms diagnosis

A

multople esposes of demaites, happening in differnt areas over a period of tiem

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16
Q

what hormone may be linked ot ms in women

A

oestrogen

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17
Q

what is a characties loss that shows progression of the disase

A

loss of the axons

18
Q

what is the progressive stage in ms

A

accumation and symtons such as furher fatique, pins and eends, stiffnes, balance and slurrend speahc, bladder probesl e.ct

19
Q

what to do in ms exam

A

pupillary defects
nystagusms or absomaly eye movements
cerebellar signs such as atraxia
weakness
spasticicyt
hyperreflexia
plantar extensor

20
Q

what are the type sof ms

A

relapsing / remitting 85%
seconary progressive
primary pregssid 10%

21
Q

what is primary progessve

A

where there is none of the relaping and remitting and it is just a deterning in ms, and cause spinal and vbldder problems
deteriatin is at a constant rate

22
Q

what is seconary progessive

A

there at first is erapinga nd remiting, then it has a general deteriating of ms that that does improve

23
Q

criteerai for mri ms diaganso

A

mcdonalds criteria

24
Q

clincial criterai for ms diagnossi

A

posers criteri - mianly 2 realpse in different area so cns months or years apart

25
what should show in a lumar punctre for ms
normal csf glucose and protin few whiet cells ooligocloant band that are just in the csf but not the serum - indicates inflation of just the spinal cord and notwerhe else
26
oligoclonat bands
indicate inflmaton inthe csf
27
differneatl diagnos sof ms inchial
acute disseminated encephalomylitis - after viral ollenss
28
differnetail diagnois of ms in adults
sarcoidosis vasculitis lyme disease tb
29
investiags for ms
lumbar punctues blood test for autoantimary screen, virolgy, b12 chest x-ray to rule out tb and sarcoidosis
30
treatemtent of acute relaspe in ms
oral prednisoloen - for 3 days with gastic protection
31
what are treatement for spacity in ms
muslce realaxsi and antispasmotics
32
treatment for dysaethesia
amitriptyline, gabapentin
33
treatment for over active unary symosn
anticholineragic rx
34
treatemt for underative urarl fuction
bladder stimualtion, seelf catheretiesation
35
other problesm as a result of cs
depression fatique tremtors viiosn - particuerl oscilliopisa speech motor and sernory impariemtn
36
treatemtn for oscillopsia
carbamazepine
37
fist line disease modify
oral - teriflunomide, dimethyl fumarate sc/ im infeciton - beta interferons, glatiramer aceetaet
38
second line disease modifiying
tablets - fingolimod/ ozanimod/ posenimod, cldridine sc injections/ iv infusions - natalizumab, ocrelizumab, ofatumumab, alemtuzumub stem cell treatemn
39
main priiamry and seconary dmt for ms
primar - ms ocrelizumab secondary - ms - siponimod
40
can immouspueeoisn be usecd
yes
41
downsie of immuo suppersion
has risk o prgessive multifocal leukoencephalopathy
42