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Pharm Midterm 2 > NNRTIs > Flashcards

Flashcards in NNRTIs Deck (25):
1

What are NNRTIs

Highly selective, non-competitive inhibitors of HIV-I RT

2

Do NNRTIs require phosphorylation

No

3

NNRTI cross resistance

Between NNRTIs, NOT NRTIs

4

Main NNRTI AE

Skin Rash - Steven Johnson

5

Which NNRTI are 3A4 inducers

Nevirapine
Etravirine
Efavirenz

6

Which NNRTI is a 3A4 inhibitor

Delavirdine

7

Which NNRTI is a 2C9, 2C19 inhibitor

Etravirine

8

What metabolizes Nevirapine

3A4
2D6

9

What are the NNRTIs

Nevirapine
Etravirine
Efavirenz
Delavirdine

10

Main Nevirapine AE

Hepatotoxicity

11

When do you not give Nevirapine

Women CD4 > 250
Men CD4 > 400

12

How does Nevirapine/Delavirdine resistance arise

Mutation at target site

13

What does non-linear kinetics mean

t1/2 increases with dose

14

Which NNRTI has non-linear kinetics

Delavirdine

15

Where is Delavirdine excreted

Kidneys

16

Delavirdine contraindication

Pregnancy

17

Delaviradine AE

HA, fever, depression

18

Who do you give Etravirine to

Treatment-experienced patients
Strains resistant to 1st line NNRTIs

19

What metabolizes Etravirine

3A4
2C9
2C19

20

Etravirine AE

N/D
Elevated transaminases (esp in hep)

21

What is the Preferred NNRTI

Efavirenz

22

What is the most common Efavirenz AE

CNS effects
Vivid Dreams

23

What happens with Efavirenz in pregnancy

Neural tube defects

24

When can you give Efavirenz in pregnancy

After 1st trimester

25

P450 effect of Efavirenz

Induction