TB Flashcards
Which TB drugs are safe in pregnancy
1st line
What are the 1st line TB drugs
Isoniazid Rifampin Rifabutin Rifapentine Ethambutol Pyrazinamide
What are the 2nd line TB drugs
Streptomycin
Ethionamide
Levofloxacin
Amikacin
What is the solo drug for latent infection
Isoniazid
Which 1st line TB is a P450 inhibitor
Isoniazid
Which 1st line TB is a P450 inducer
Rifampin
Which 1st line is specific for TB
Isoniazid
Which 1st line TB can cause SLE
Isoniazid
What is the DOC for TB with AIDS
Rifabutin
Which 1st line TB can cause orange body fluids
Rifampin
Which 1st line TB can cause red/green colourblindness
Ethambutol
Which 1st line can cause Non-gouty Polyarthralgia
Pyrazinamide
When is Isoniazid -static
Stationary phase
When is Isoniazid -cidal
Dividing
How does Isoniazid work
Activated by KatG (catalase-peroxidase)
Inhibits InhA and KasA
Decreased Mycolic Acid = No cell wall
What is Isoniazid an analog of
Pyridoxine (Supplement B6)
What are the Isoniazid AE
Peripheral neuritis
Hepatotoxicity
Does Isoniazid have cross resistance
No
Isoniazid ROA
Oral
IV
Im
What can the Rifampins act on
TB
M. kansasii
What do the Rifampins act on clinically
TB, Leprosy
Meningitis prophylaxis
MRSA (with Vanco)
How does Rifampin work
Binds Beta subunit of RNAP
No RNA synth
What are the Rifampin AE
Thrombocytopenia Rash Nephritis Liver dysfunction Proteinuria GI distress
Mechanism of Rifampin resistance
Point mutation in rpoB gene
Decreased permeability
